Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/97508
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dc.contributor.author | Tajik, P. | - |
dc.contributor.author | van der Ham, D. | - |
dc.contributor.author | Zafarmand, M. | - |
dc.contributor.author | Hof, M. | - |
dc.contributor.author | Morris, J. | - |
dc.contributor.author | Franssen, M. | - |
dc.contributor.author | de Groot, C. | - |
dc.contributor.author | Duvekot, J. | - |
dc.contributor.author | Oudijk, M. | - |
dc.contributor.author | Willekes, C. | - |
dc.contributor.author | Bloemenkamp, K. | - |
dc.contributor.author | Porath, M. | - |
dc.contributor.author | Woiski, M. | - |
dc.contributor.author | Akerboom, B. | - |
dc.contributor.author | Sikkema, J. | - |
dc.contributor.author | Bijvank, B. | - |
dc.contributor.author | Mulder, A. | - |
dc.contributor.author | Bossuyt, P. | - |
dc.contributor.author | Mol, B. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | BJOG: an International Journal of Obstetrics and Gynaecology, 2014; 121(10):1263-1272 | - |
dc.identifier.issn | 1470-0328 | - |
dc.identifier.issn | 1471-0528 | - |
dc.identifier.uri | http://hdl.handle.net/2440/97508 | - |
dc.description | Article first published online: 27 MAY 2014 | - |
dc.description.abstract | OBJECTIVE: To investigate whether vaginal Group B Streptococcus (GBS) colonisation or other baseline characteristics of women with preterm premature rupture of membranes (PPROM) can help in identifying subgroups of women who would benefit from immediate delivery. DESIGN: Secondary analysis of the PPROMEXIL trials. SETTING: Sixty hospitals in the Netherlands. POPULATION: Women with PPROM between 34 and 37 weeks of gestation. METHODS: Random assignment of 723 women to immediate delivery or expectant management. MAIN OUTCOME MEASURES: Early onset neonatal sepsis. RESULTS: Vaginal GBS colonisation status was the only marker which was significantly associated with the benefit of immediate delivery (P for interaction: 0.04). GBS colonisation was observed in 14% of women. The risk of early onset neonatal sepsis in GBS-positive women was high (15.2%) when they were managed expectantly but this risk was reduced to 1.8% with immediate delivery. The early onset neonatal sepsis risk was much lower in neonates of GBS-negative women: 2.6% after expectant management and 2.9% with immediate delivery. We estimated that by inducing labour only in GBS-positive women, there would be a 10.4% increase in term delivery rate, while keeping neonatal sepsis and caesarean delivery rates comparable to a strategy of labour induction for all. CONCLUSIONS: Our post hoc findings suggest that women with PROM between 34 and 37 weeks might benefit from immediate delivery if they have GBS vaginal colonisation, while in GBS-negative women labour induction could be delayed until 37 weeks. | - |
dc.description.statementofresponsibility | P Tajik, DP van der Ham, MH Zafarmand, MHP Hof, J Morris, MTM Franssen, CJM de Groot, JJ Duvekot, MA Oudijk, C Willekes, KWM Bloemenkamp, M Porath, M Woiski, BM Akerboom, JM Sikkema, B Nij Bijvank, ALM Mulder, PM Bossuyt, BWJ Mol | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2014 Royal College of Obstetricians and Gynaecologists | - |
dc.source.uri | http://dx.doi.org/10.1111/1471-0528.12889 | - |
dc.subject | Early onset neonatal sepsis; group B streptococcus; preterm premature rupture of membranes; treatment selection marker; vaginal culture | - |
dc.title | Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/1471-0528.12889 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mol, B. [0000-0001-8337-550X] | - |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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