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https://hdl.handle.net/2440/97632
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dc.contributor.author | Kaandorp, J. | - |
dc.contributor.author | van Den Broek, M. | - |
dc.contributor.author | Benders, M. | - |
dc.contributor.author | Oudijk, M. | - |
dc.contributor.author | Porath, M. | - |
dc.contributor.author | Oetomo, S. | - |
dc.contributor.author | Wouters, M. | - |
dc.contributor.author | van Elburg, R. | - |
dc.contributor.author | Franssen, M. | - |
dc.contributor.author | Bos, A. | - |
dc.contributor.author | Mol, B. | - |
dc.contributor.author | Visser, G. | - |
dc.contributor.author | van Bel, F. | - |
dc.contributor.author | Rademaker, C. | - |
dc.contributor.author | Derks, J. | - |
dc.contributor.author | De Haan, T. | - |
dc.contributor.author | Boon, J. | - |
dc.contributor.author | De Boer, I. | - |
dc.contributor.author | Rijnders, R. | - |
dc.contributor.author | Jacobs, C. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Archives of Disease in Childhood: Fetal and Neonatal Edition, 2014; 99(2):F144-F148 | - |
dc.identifier.issn | 1359-2998 | - |
dc.identifier.issn | 1468-2052 | - |
dc.identifier.uri | http://hdl.handle.net/2440/97632 | - |
dc.description.abstract | OBJECTIVE: Perinatal hypoxia-induced free radical formation is an important cause of hypoxic-ischaemic encephalopathy and subsequent neurodevelopmental disabilities. Allopurinol reduces the formation of free radicals, which potentially limits hypoxia-induced brain damage. We investigated placental transfer and safety of allopurinol after maternal allopurinol treatment during labour to evaluate its potential role as a neuroprotective agent in suspected fetal hypoxia. DESIGN: We used data from a randomised, double-blind multicentre trial comparing maternal allopurinol versus placebo in case of imminent fetal hypoxia (NCT00189007). PATIENTS: We studied 58 women in labour at term, with suspected fetal hypoxia prompting immediate delivery, in the intervention arm of the study. SETTING: Delivery rooms of 11 Dutch hospitals. INTERVENTION: 500 mg allopurinol, intravenously to the mother, immediately prior to delivery. MAIN OUTCOME MEASURES: Drug disposition (maternal plasma concentrations, cord blood concentrations) and drug safety (maternal and fetal adverse events). RESULTS: Within 5 min after the end of maternal allopurinol infusion, target plasma concentrations of allopurinol of ≥2 mg/L were present in cord blood. Of all analysed cord blood samples, 95% (52/55) had a target allopurinol plasma concentration at the moment of delivery. No adverse events were observed in the neonates. Two mothers had a red and/or painful arm during infusion. CONCLUSIONS: A dose of 500 mg intravenous allopurinol rapidly crosses the placenta and provides target concentrations in 95% of the fetuses at the moment of delivery, which makes it potentially useful as a neuroprotective agent in perinatology with very little side effects. TRIAL REGISTRATION: The study is registered in the Dutch Trial Register (NTR1383) and the Clinical Trials protocol registration system (NCT00189007). | - |
dc.description.statementofresponsibility | J J Kaandorp, M P H van den Broek, M J N L Benders, M A Oudijk, M M Porath, S Bambang Oetomo, M G A J Wouters, Ruurd van Elburg, M T M Franssen, A F Bos, B W J Mol, G H A Visser, F van Bel, C M A Rademaker, J B Derks, for the ALLO-trial Study Group | - |
dc.language.iso | en | - |
dc.publisher | BMJ Publishing Group | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.1136/archdischild-2013-304876 | - |
dc.subject | ALLO-trial Study Group | - |
dc.subject | Fetal Blood | - |
dc.subject | Fetus | - |
dc.subject | Placenta | - |
dc.subject | Hypoxia-Ischemia, Brain | - |
dc.subject | Free Radicals | - |
dc.subject | Allopurinol | - |
dc.subject | Neuroprotective Agents | - |
dc.subject | Free Radical Scavengers | - |
dc.subject | Double-Blind Method | - |
dc.subject | Pregnancy | - |
dc.subject | Labor, Obstetric | - |
dc.subject | Maternal-Fetal Exchange | - |
dc.subject | Infant, Newborn | - |
dc.subject | Fetal Hypoxia | - |
dc.title | Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/archdischild-2013-304876 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mol, B. [0000-0001-8337-550X] | - |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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