Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9824
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Type: Journal article
Title: Zinc protects against arsenic induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity
Author: Milton, A.
Zalewski, P.
Ratnaike, R.
Citation: Biometals, 2004; 17(6):707-713
Publisher: Kluwer Academic Publ
Issue Date: 2004
ISSN: 0966-0844
1572-8773
Statement of
Responsibility: 
Austin Graham Milton, Peter David Zalewski and Ranjit Nihal Ratnaike
Abstract: Acute and chronic arsenic exposure results in toxicity in humans and causes many neurological and other manifestations. For the first time the present study reports that zinc decreases arsenic-induced apoptosis and also confirms a single report of apoptosis induced by arsenic in a neuronal cell line. Apoptosis measured by DEVD-caspase activity peaked between 10 M and 20 M of arsenic trioxide. Higher concentrations of arsenic up to 40 M caused increasing cell death with diminishing DEVD-caspase activity. The beneficial effect of zinc was proportional to its concentration with a significant decrease in arsenic-induced DEVD-caspase activity at 50 M and 75 M zinc (P<0.05). This finding may be of therapeutic benefit in people suffering from chronic exposure to arsenic from natural sources, a global problem especially relevant to millions of people on the Indian subcontinent.
Keywords: Neurons
Cell Line
Animals
Mice
Arsenicals
Oxides
Zinc
Zinc Sulfate
Sodium Oxybate
Caspases
Enzyme Inhibitors
Apoptosis
Enzyme Activation
Dose-Response Relationship, Drug
Phenotype
Time Factors
Arsenic Trioxide
Description: The original publication is available at www.springerlink.com
DOI: 10.1007/s10534-004-1210-3
Published version: http://dx.doi.org/10.1007/s10534-004-1210-3
Appears in Collections:Aurora harvest
Medicine publications

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