Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9851
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorStepien, J.en
dc.contributor.authorPrideaux, R.en
dc.contributor.authorWilloughby, S.en
dc.contributor.authorChirkov, Y.en
dc.contributor.authorHorowitz, J.en
dc.date.issued2003en
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 2003; 30(7):507-512en
dc.identifier.issn0305-1870en
dc.identifier.issn1440-1681en
dc.identifier.urihttp://hdl.handle.net/2440/9851-
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstract1. Hypercholesterolaemia has been associated with impaired endothelial function. However, there are no available data as to whether hypercholesterolaemia is also associated with platelet dysfunction. 2. In a group of asymptomatic adults with (n = 16) and without (n = 13) mild hypercholesterolaemia, we evaluated inhibition of platelet aggregation in response to the nitric oxide (NO) donor sodium nitroprusside (SNP), as well as the augmentation index (AIx), a parameter of arterial stiffness that is impaired in the presence of endothelial dysfunction. 3. Neither SNP response nor AIx varied significantly between normocholesterolaemic (NC) and hypercholesterolaemic (HC) subjects. 4. Three months treatment with pravastatin (40 mg/day) in HC subjects lowered mean (±SEM) total cholesterol levels from 6.6 ± 0.2 to 5.5 ± 0.2 mmol/L. Platelet response to SNP increased in platelet-rich plasma and tended to increase in whole blood. The AIx did not change significantly. However, falls in low-density lipoprotein (P = 0.03) and total cholesterol (P = 0.08) correlated with reductions in AIx in individual subjects. 5. These data provide evidence that moderate reduction of cholesterol levels may improve platelet responses to NO, whereas improvement in arterial stiffness may be detectable only with more extensive and/or a prolonged reduction in cholesterol levels.en
dc.description.statementofresponsibilityJacqueline M Stepien, Rhonda M Prideaux, Scott R Willoughby, Yuliy Y Chirkov and John D Horowitzen
dc.language.isoenen
dc.publisherBlackwell Science Asiaen
dc.source.urihttp://www.blackwell-synergy.com/doi/full/10.1046/j.1440-1681.2003.03859.xen
dc.subjectArteries; Blood Platelets; Humans; Hypercholesterolemia; Nitric Oxide; Pravastatin; Cholesterol; Nitric Oxide Donors; Anticholesteremic Agents; Pilot Projects; Vascular Resistance; Adult; Middle Aged; Female; Maleen
dc.titlePilot study examining the effect of cholesterol lowering on platelet nitric oxide responsiveness and arterial stiffness in subjects with isolated mild hypercholesterolaemiaen
dc.typeJournal articleen
dc.identifier.rmid0020030098en
dc.identifier.doi10.1046/j.1440-1681.2003.03859.xen
dc.identifier.pubid59080-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, J. [0000-0001-6883-0703]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.