Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98600
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dc.contributor.authorAnderson, E.en
dc.contributor.authorHowe, L.en
dc.contributor.authorFraser, A.en
dc.contributor.authorMacdonald-Wallis, C.en
dc.contributor.authorCallaway, M.en
dc.contributor.authorSattar, N.en
dc.contributor.authorDay, C.en
dc.contributor.authorTilling, K.en
dc.contributor.authorLawlor, D.en
dc.date.issued2015en
dc.identifier.citationThe Journal of Nutrition, 2015; 145(5):983-989en
dc.identifier.issn0022-3166en
dc.identifier.issn1541-6100en
dc.identifier.urihttp://hdl.handle.net/2440/98600-
dc.descriptionFirst published March 18, 2015en
dc.description.abstractGreater adiposity is an important risk factor for nonalcoholic fatty liver disease (NAFLD). Thus, it is likely that dietary intake is involved in the development of the disease. Prospective studies assessing the relation between childhood dietary intake and risk of NAFLD are lacking.This study was designed to explore associations between energy, carbohydrate, sugar, starch, protein, monounsaturated fat, polyunsaturated fat, saturated fat, and total fat intake by youth at ages 3, 7, and 13 y and subsequent (mean age: 17.8 y) ultrasound scan (USS)-measured liver fat and stiffness and serum alanine aminotransferase, aspartate aminotransferase, and ╬│-glutamyltransferase. We assessed whether observed associations were mediated through fat mass at the time of outcome assessment.Participants were from the Avon Longitudinal Study of Parents and Children. Trajectories of energy and macronutrient intake from ages 3-13 y were obtained with linear-spline multilevel models. Linear and logistic regression models examined whether energy intake and absolute and energy-adjusted macronutrient intake at ages 3, 7, and 13 y were associated with liver outcomes.Energy intake at all ages was positively associated with liver outcomes; for example, the odds of having a USS-measured liver fat per 100 kcal increase in energy intake at age 3 y were 1.79 (95% CI: 1.14, 2.79). Associations between absolute macronutrient intake and liver outcomes were inconsistent and attenuated to the null after adjustment for total energy intake. The majority of associations attenuated to the null after adjustment for fat mass at the time liver outcomes were assessed.Higher childhood and early adolescent energy intake is associated with greater NAFLD risk, and the macronutrients from which energy intake is derived are less important. These associations appear to be mediated, at least in part, by fat mass at the time of outcome assessment.en
dc.description.statementofresponsibilityEmma L Anderson, Laura D Howe, Abigail Fraser, Corrie Macdonald-Wallis, Mark P Callaway, Naveed Sattar, Chris Day, Kate Tilling, and Debbie A Lawloren
dc.language.isoenen
dc.publisherAmerican Society for Nutritionen
dc.rightsThis is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).en
dc.subjectdiet; energy intake; childhood; NAFLD; fatty liveren
dc.titleChildhood energy intake is associated with nonalcoholic fatty liver disease in adolescentsen
dc.typeJournal articleen
dc.identifier.rmid0030041733en
dc.identifier.doi10.3945/jn.114.208397en
dc.identifier.pubid232679-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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