Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98701
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSharp, G.en
dc.contributor.authorLawlor, D.en
dc.contributor.authorRichmond, R.en
dc.contributor.authorFraser, A.en
dc.contributor.authorSimpkin, A.en
dc.contributor.authorSuderman, M.en
dc.contributor.authorShihab, H.en
dc.contributor.authorLyttleton, O.en
dc.contributor.authorMcArdle, W.en
dc.contributor.authorRing, S.en
dc.contributor.authorGaunt, T.en
dc.contributor.authorSmith, G.en
dc.contributor.authorRelton, C.en
dc.date.issued2015en
dc.identifier.citationInternational Journal of Epidemiology, 2015; 44(4):1288-1304en
dc.identifier.issn0300-5771en
dc.identifier.issn1464-3685en
dc.identifier.urihttp://hdl.handle.net/2440/98701-
dc.description.abstractEvidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism.We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA methylation in relation to maternal and offspring adiposity in 1018 participants.Compared with neonatal offspring of normal weight mothers, 28 and 1621 CpG sites were differentially methylated in offspring of obese and underweight mothers, respectively [false discovert rate (FDR)-corrected P-value < 0.05), with no overlap in the sites that maternal obesity and underweight relate to. A positive association, where higher methylation is associated with a body mass index (BMI) outside the normal range, was seen at 78.6% of the sites associated with obesity and 87.9% of the sites associated with underweight. Associations of maternal obesity with offspring methylation were stronger than associations of paternal obesity, supporting an intrauterine mechanism. There were no consistent associations of gestational weight gain with offspring DNA methylation. In general, sites that were hypermethylated in association with maternal obesity or hypomethylated in association with maternal underweight tended to be positively associated with offspring adiposity, and sites hypomethylated in association with maternal obesity or hypermethylated in association with maternal underweight tended to be inversely associated with offspring adiposity.Our data suggest that both maternal obesity and, to a larger degree, underweight affect the neonatal epigenome via an intrauterine mechanism, but weight gain during pregnancy has little effect. We found some evidence that associations of maternal underweight with lower offspring adiposity and maternal obesity with greater offspring adiposity may be mediated via increased DNA methylation.en
dc.description.statementofresponsibilityGemma C Sharp, Debbie A Lawlor, Rebecca C Richmond, Abigail Fraser, Andrew Simpkin, Matthew Suderman, Hashem A Shihab, Oliver Lyttleton, Wendy McArdle, Susan M Ring, Tom R Gaunt, George Davey Smith and Caroline L Reltonen
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association 1288 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectEpigenetic; ALSPAC; ARIES; causality; epigenome-wide; association study; longitudinal; overweight; overnutritin; undernutritionen
dc.titleMaternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: Findings from the Avon Longitudinal Study of Parents and Childrenen
dc.typeJournal articleen
dc.identifier.rmid0030041730en
dc.identifier.doi10.1093/ije/dyv042en
dc.identifier.pubid232675-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_98701.pdfPublished version1.58 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.