Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9872
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure
Author: Anderson, R.
Ellis, G.
Chirkov, Y.
Holmes, A.
Payne, N.
Blackman, D.
Jackson, S.
Lewis, M.
Horowitz, J.
Frenneaux, M.
Citation: European Journal of Heart Failure, 2004; 6(1):47-54
Publisher: Elsevier Science BV
Issue Date: 2004
ISSN: 1388-9842
1879-0844
Statement of
Responsibility: 
R.A. Anderson, G.R. Ellis, Y.Y. Chirkov, A.S. Holmes, N. Payne, D.J. Blackman, S.K. Jackson, M.J. Lewis, J.D. Horowitz, M.P. Frenneaux
Abstract: Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p<0.05).
Keywords: Humans; Nitroprusside; Nitric Oxide Donors; Angiotensin-Converting Enzyme Inhibitors; Cell Culture Techniques; Severity of Illness Index; Case-Control Studies; Age Factors; Oxidative Stress; Platelet Aggregation; Adult; Aged; Middle Aged; Female; Male; Heart Failure
Rights: © 2003 European Society of Cardiology. Published by Elsevier B.V.All rights reserved.
RMID: 0020040015
DOI: 10.1016/S1388-9842(03)00038-2
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.