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|Title:||Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure|
|Citation:||European Journal of Heart Failure, 2004; 6(1):47-54|
|Publisher:||Elsevier Science BV|
|R.A. Anderson, G.R. Ellis, Y.Y. Chirkov, A.S. Holmes, N. Payne, D.J. Blackman, S.K. Jackson, M.J. Lewis, J.D. Horowitz, M.P. Frenneaux|
|Abstract:||Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2- in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p<0.05).|
|Keywords:||Humans; Nitroprusside; Nitric Oxide Donors; Angiotensin-Converting Enzyme Inhibitors; Cell Culture Techniques; Severity of Illness Index; Case-Control Studies; Age Factors; Oxidative Stress; Platelet Aggregation; Adult; Aged; Middle Aged; Female; Male; Heart Failure|
|Rights:||© 2003 European Society of Cardiology. Published by Elsevier B.V.All rights reserved.|
|Appears in Collections:||Medicine publications|
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