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Type: Journal article
Title: Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans
Author: Zeitz, C.
Campbell, D.
Horowitz, J.
Citation: Hypertension, 2003; 41(3):482-487
Publisher: Lippincott Williams & Wilkins
Issue Date: 2003
ISSN: 0194-911X
Statement of
Christopher J. Zeitz, Duncan J. Campbell, and John D. Horowitz
Abstract: There is little information on the processes affecting selective tissue ACE inhibition and the implications in human subjects. We compared intravenously administered ACE inhibitors, perindoprilat and enalaprilat, for myocardial drug uptake and effects on angiotensin and bradykinin peptides versus hemodynamic effects in 25 patients with stable angina and well-preserved left ventricular systolic function. Myocardial uptake was rapid and more efficient for perindoprilat than for enalaprilat (peak content at 26+/-3 and 30+/-4 seconds, 0.58+/-0.12% and 0.27+/-0.07% of the administered dose for perindoprilat and enalaprilat, respectively, P=0.04 for difference). Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood. Bradykinin (BK)-(1-9) and BK-(1-8) levels increased in arterial blood and BK-(1-8) levels increased in coronary sinus blood after drug administration. Perindoprilat and enalaprilat caused a small decrease in mean arterial pressure (-3+/-1%, P<0.05; and -4+/-1%, P<0.01, respectively) and LV+dP/dt (-5.8+/-1.7%, P<0.01 and -4.2+/-2.8%, P<0.05, respectively), whereas systemic vascular resistance index was unchanged. Despite relatively cardioselective uptake of perindoprilat, both drugs had similar effects on the cardiac metabolism of angiotensin and bradykinin and on cardiac function. Under resting conditions, both drugs exerted small negative inotropic effects.
Keywords: metabolism; hemodynamics; bradykinin; angiotensin; myocardium; enalapril
Description: © 2003 American Heart Association. All rights reserved.
RMID: 0020030299
DOI: 10.1161/01.HYP.0000054976.67487.08
Appears in Collections:Medicine publications

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