Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98983
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Type: Journal article
Title: Combined effects of muricid extract and 5-fluorouracil on intestinal toxicity in rats
Author: Yazbeck, R.
Lindsay, R.
Abbott, C.
Benkendorff, K.
Howarth, G.
Citation: Evidence-Based Complementary and Alternative Medicine, 2015; 2015:170858-1-170858-9
Publisher: Hindawi Publishing Corporation
Issue Date: 2015
ISSN: 1741-427X
1741-4288
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Responsibility: 
Roger Yazbeck, Ruth Lindsay, Catherine A. Abbott, Kirsten Benkendorff and Gordon S. Howarth
Abstract: Chemotherapy drugs, such as 5-fluorouracil (5FU), are the standard approach for cancer and are associated with several peripheral toxicities. We previously demonstrated that Muricidae marine molluscs exhibit chemopreventive properties. This study investigated the combined effect of muricid extract derived from Dicathais orbita, with 5FU, on intestinal toxicity in rats. Groups of rats were orally gavaged water, muricid extract, or sunflower oil, with or without 5FU (150 mg/kg). Metabolic data was collected daily and small intestinal brush border enzyme activity was measured by sucrose breath test (SBT). Blood was collected by cardiac puncture for whole blood analysis. Intestinal biopsies were taken for histopathology. Neutrophil activity was measured by myeloperoxidase activity. No additional toxicity effects were observed in rats receiving the combination of 5FU and muricid extract compared to 5FU alone, as indicated by SBT, histopathology, and myeloperoxidase activity. Intestinal integrity was protected from 5FU-induced damage in the sunflower oil vehicle group, compared to controls, as measured by SBT, villus height, and crypt depth. We concluded that combination of muricid extract and 5FU did not confer any additional intestinal toxicity, further supporting its potential as a chemopreventive food product. In this model system, sunflower oil partially protected against 5FU-induced intestinal toxicity.
Rights: © 2015 Roger Yazbeck et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030030635
DOI: 10.1155/2015/170858
Appears in Collections:Animal and Veterinary Sciences publications

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