Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99130
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Type: | Journal article |
Title: | Associations of existing diabetes, gestational diabetes, and glycosuria with offspring IQ and educational attainment: The Avon Longitudinal Study of Parents and Children |
Author: | Fraser, A. Nelson, S. MacDonald-Wallis, C. Lawlor, D. |
Citation: | Journal of Diabetes Research, 2012; 2012:963735-1-963735-7 |
Publisher: | Hindawi Publishing Corporation |
Issue Date: | 2012 |
ISSN: | 1687-5214 1687-5303 |
Statement of Responsibility: | Abigail Fraser, ScottM. Nelson, CorrieMacdonald-Wallis, and Debbie A. Lawlor |
Abstract: | Introduction. Results from studies examining associations of maternal diabetes in pregnancy with offspring cognitive outcomes have been inconclusive. Methods. We used data from the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort. Outcomes were School Entry Assessment (SEA) scores (age 4, N = 6, 032) and WISC-III IQ (age 8, N = 5, 282–5, 307) and General Certificate of Secondary Education (GCSE) results (age 16, N = 7, 615). Results. Existing diabetes, gestational diabetes, and, to a lesser extent, glycosuria were associated with lower offspring SEA scores (age 4), IQ (age 8), and GCSE results (age 16) even when adjusting for offspring sex, maternal age, prepregnancy BMI, smoking in pregnancy, parity, caesarean section, maternal education, and occupational social class. Offspring of mothers with existing diabetes had a threefold risk of achieving no GCSEs graded A∗-C, whilst offspring of women with gestational diabetes had, on average, a five point lower IQ compared to offspring of women with no diabetes or glycosuria. Conclusions. Maternal diabetes in pregnancy is consistently associated with lower offspring cognition and educational attainment though confidence intervals were wide. The weaker associations with glycosuria suggest a dose-dependent adverse association with IQ. |
Keywords: | Humans |
Rights: | Copyright © 2012 Abigail Fraser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1155/2012/963735 |
Published version: | http://dx.doi.org/10.1155/2012/963735 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_99130.pdf | Published version | 1.29 MB | Adobe PDF | View/Open |
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