Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99158
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Type: Journal article
Title: Effect of N-acetylcysteine on cycling performance after intensified training
Author: Slattery, K.
Dascombe, B.
Wallace, L.
Bentley, D.
Coutts, A.
Citation: Medicine and Science in Sports and Exercise, 2014; 46(6):1114-1123
Publisher: American College of Sports Medicine (ACSM)
Issue Date: 2014
ISSN: 0195-9131
1530-0315
Statement of
Responsibility: 
Katie May Slattery, Ben Dascombe, Lee Kenneth Wallace, David J. Bentley, and Aaron James Coutts
Abstract: Purpose: This investigation examined the ergogenic effect of short-term oral N-acetylcysteine (NAC) supplementation and the associated changes in redox balance and inflammation during intense training. Methods: A double-blind randomized placebo-controlled crossover design was used to assess 9 d of oral NAC supplementation (1200 mgIdj1) in 10 well-trained triathletes. For each supplement trial (NAC and placebo), baseline venous blood and urine samples were taken, and a presupplementation cycle ergometer race simulation was performed. After the loading period, further samples were collected preexercise, postexercise, and 2 and 24 h after the postsupplementation cycle ergometer race simulation. Changes in total antioxidant capacity, ferric reducing ability of plasma, reduced glutathione, oxidized glutathione, thiobarbituric acid-reactive substances, interleukin 6, xanthine oxidase, hypoxanthine, monocyte chemotactic protein 1, nuclear factor JB, and urinary 15-isoprostane F2t concentration were assessed. The experimental procedure was repeated with the remaining supplement after a 3-wk washout. Eight participants completed both supplementation trials. Results: NAC improved sprint performance during the cycle ergometer race simulation (P G 0.001, Gp 2 = 0.03). Supplementation with NAC also augmented postexercise plasma total antioxidant capacity (P = 0.005, Gp 2 = 0.19), reduced exercise-induced oxidative damage (plasma thiobarbituric acid-reactive substances, P = 0.002, Gp 2 = 0.22; urinary 15-isoprostane F2t concentration, P = 0.010, Gp 2 = 0.431), attenuated inflammation (plasma interleukin 6, P = 0.002, Gp 2 = 0.22; monocyte chemotactic protein 1, P = 0.012, Gp 2 = 0.17), and increased postexercise nuclear factor JB activity (P G 0.001, Gp 2 = 0.21). Conclusion: Oral NAC supplementation improved cycling performance via an improved redox balance and promoted adaptive processes in well-trained athletes undergoing strenuous physical training.
Keywords: Antioxidant; Oxidative stress; Inflammation; Nuclear factor κB
Rights: Copyright © 2014 by the American College of Sports Medicine
RMID: 0030010932
DOI: 10.1249/MSS.0000000000000222
Appears in Collections:Medical Sciences publications

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