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|Title:||Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review|
|Citation:||Clinical and Experimental Ophthalmology, 2016; 44(3):188-195|
|Paul I Sia, John PM Wood, Glyn Chidlow, Shiwani Sharma, Jamie Craig and Robert J Casson|
|Abstract:||The nucleolus has emerged as a key regulator of cellular growth and the response to stress, in addition to its traditionally understood function in ribosome biogenesis. The association between nucleolar function and neurodegenerative disease is increasingly being explored. There is also recent evidence indicating that the nucleolus may well be crucial in the development of the eye. In this present review, the role of the nucleolus in retinal development as well as in neurodegeneration with an emphasis on the retina is discussed.|
|Keywords:||glaucoma; neurodegeneration; nucleolar stress; nucleolus; retinal development|
|Description:||Version of Record online: 5 FEB 2016|
|Rights:||© 2015 Royal Australian and New Zealand College of Ophthalmologists|
|Appears in Collections:||Opthalmology & Visual Sciences publications|
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