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Type: Journal article
Title: Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review
Author: Sia, P.
Wood, J.
Chidlow, G.
Sharma, S.
Craig, J.
Casson, R.
Citation: Clinical and Experimental Ophthalmology, 2016; 44(3):188-195
Publisher: Wiley
Issue Date: 2016
ISSN: 1442-6404
Statement of
Paul I Sia, John PM Wood, Glyn Chidlow, Shiwani Sharma, Jamie Craig and Robert J Casson
Abstract: The nucleolus has emerged as a key regulator of cellular growth and the response to stress, in addition to its traditionally understood function in ribosome biogenesis. The association between nucleolar function and neurodegenerative disease is increasingly being explored. There is also recent evidence indicating that the nucleolus may well be crucial in the development of the eye. In this present review, the role of the nucleolus in retinal development as well as in neurodegeneration with an emphasis on the retina is discussed.
Keywords: glaucoma; neurodegeneration; nucleolar stress; nucleolus; retinal development
Description: Version of Record online: 5 FEB 2016
Rights: © 2015 Royal Australian and New Zealand College of Ophthalmologists
RMID: 0030038379
DOI: 10.1111/ceo.12661
Grant ID:
Appears in Collections:Opthalmology & Visual Sciences publications

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