Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99422
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Type: Journal article
Title: Sterile inflammation in drosophila
Author: Shaukat, Z.
Liu, D.
Gregory, S.
Citation: Mediators of Inflammation, 2015; 2015:369286-1-369286-7
Publisher: Hindawi Publishing Corporation
Issue Date: 2015
ISSN: 0962-9351
1466-1861
Statement of
Responsibility: 
Zeeshan Shaukat, Dawei Liu, and Stephen Gregory
Abstract: The study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to damage signals rather than pathogens, particularly damage signals from tumour-like tissues generated by loss of cell polarity or chromosomal instability. Both the triggers that generate this sterile inflammation and the systemic and local effects of it are only just beginning to be characterized in Drosophila. Here we review the molecular mechanisms that are known that give rise to the recruitment of Drosophila phagocytes, called hemocytes, as well as the signals, such as TNFα, that stimulated hemocytes emit at sites of perceived damage. The signalling consequences of inflammation, such as the activation of JNK, and the potential for modifying this response are also discussed.
Keywords: Inflammation
Rights: Copyright © 2015 Zeeshan Shaukat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030030260
DOI: 10.1155/2015/369286
Appears in Collections:Genetics publications

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