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https://hdl.handle.net/2440/101837
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Type: | Journal article |
Title: | Emergence of carbapenem-resistant Acinetobacter baumannii in hospitals in Pakistan |
Author: | Hasan, B. Perveen, K. Olsen, B. Zahra, R. |
Citation: | Journal of Medical Microbiology, 2014; 63(1):50-55 |
Publisher: | Microbiology Society |
Issue Date: | 2014 |
ISSN: | 0022-2615 1473-5644 |
Statement of Responsibility: | Badrul Hasan, Khalida Perveen, Bjo, rn Olsen and Rabaab Zahra |
Abstract: | The emergence of pan-resistance in bacterial pathogens poses a threat to human health. Carbapenem-resistant Acinetobacter baumannii has emerged as a serious challenge, causing nosocomial infection and community-acquired outbreaks in hospitals globally, including in Pakistan. We collected 90 Acinetobacter isolates from patients with secondary or nosocomial infections from different hospitals in Pakistan and screened for carbapenem-resistant strains. Of the 90 isolates, 59 were resistant to carbapenems. Among oxacillinase -encoding genes, blaOXA-51-like was common in all isolates, including in combination with blaOXA-23-like in 14 isolates; however, blaOXA-24-like and blaOXA-58-like were completely absent. Among metallo-β-lactamase-encoding genes, only blaNDM-1 was found in one isolate, while the other three genes, blaIMP, blaVIM and blaSIM, were completely absent. None of the isolates was found to harbour the blaCTX-M gene. The isolates were also tested for susceptibilities to a panel of different antibiotics belonging to several classes. Of all the drugs tested, tigecycline was the most effective with 80 % sensitivity amongst isolates, followed by colistin with 50 % sensitivity. Three categories of resistance were found in these isolates: extreme drug resistance in 26, pan-drug resistance in 19 and multidrug resistance in 87 isolates. The isolates exhibited a high resistance to cephalosporins, trimethoprim-sulfamethoxazole and β-lactam antibiotics, followed by tetracycline and β-lactam/β-lactam inhibitor combination, fluoroquinolone and aminoglycosides. The results show a prominent level of antibiotic-resistance phenotypes in A. baumannii and strongly suggest the need for full-scale national surveillance of carbapenem-resistant A. baumannii with particular emphasis on the newly identified NDM-1 (New Delhi metallo-β-lactamase-1). |
Keywords: | Cross Infection |
Description: | Published Online: 01/01/2014 |
Rights: | © 2014 SGM |
DOI: | 10.1099/jmm.0.063925-0 |
Published version: | http://dx.doi.org/10.1099/jmm.0.063925-0 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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