Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/102025
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dc.contributor.author | Weisenberger, D. | - |
dc.contributor.author | Levine, A. | - |
dc.contributor.author | Long, T. | - |
dc.contributor.author | Buchanan, D. | - |
dc.contributor.author | Walters, R. | - |
dc.contributor.author | Clendenning, M. | - |
dc.contributor.author | Rosty, C. | - |
dc.contributor.author | Joshi, A. | - |
dc.contributor.author | Stern, M. | - |
dc.contributor.author | Le Marchand, L. | - |
dc.contributor.author | Lindor, N. | - |
dc.contributor.author | Daftary, D. | - |
dc.contributor.author | Gallinger, S. | - |
dc.contributor.author | Selander, T. | - |
dc.contributor.author | Bapat, B. | - |
dc.contributor.author | Newcomb, P. | - |
dc.contributor.author | Campbell, P. | - |
dc.contributor.author | Casey, G. | - |
dc.contributor.author | Ahnen, D. | - |
dc.contributor.author | Baron, J. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Cancer Epidemiology, Biomarkers and Prevention, 2015; 24(3):512-519 | - |
dc.identifier.issn | 1055-9965 | - |
dc.identifier.issn | 1538-7755 | - |
dc.identifier.uri | http://hdl.handle.net/2440/102025 | - |
dc.description.abstract | Background: The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known. Methods: We measured the CIMP status of 3,119 primary population-based colorectal cancer tumors from the multinational Colon Cancer Family Registry. Etiologic heterogeneity was assessed by a case–case study comparing risk factor frequency of colorectal cancer cases with CIMP and non-CIMP tumors using logistic regression to estimate the case–case odds ratio (ccOR). Results: We found associations between tumor CIMP status and MSI-H (ccOR = 7.6), BRAF V600E mutation (ccOR = 59.8), proximal tumor site (ccOR = 9; all P < 0.0001), female sex [ccOR = 1.8; 95% confidence interval (CI), 1.5–2.1], older age (ccOR = 4.0 comparing over 70 years vs. under 50; 95% CI, 3.0–5.5), and family history of CRC (ccOR = 0.6; 95% CI, 0.5–0.7). While use of NSAIDs varied by tumor CIMP status for both males and females (P = 0.0001 and P = 0.02, respectively), use of multivitamin or calcium supplements did not. Only for female colorectal cancer was CIMP status associated with increased pack-years of smoking (Ptrend < 0.001) and body mass index (BMI; Ptrend = 0.03). Conclusions: The frequency of several colorectal cancer risk factors varied by CIMP status, and the associations of smoking and obesity with tumor subtype were evident only for females. Impact: Differences in the associations of a unique DNA methylation–based subgroup of colorectal cancer with important lifestyle and environmental exposures increase understanding of the molecular pathologic epidemiology of this heavily methylated subset of colorectal cancer. | - |
dc.description.statementofresponsibility | D.J. Weisenberger ... J.P. Young et al. (for the Colon Cancer Family Registry) | - |
dc.language.iso | en | - |
dc.publisher | American Association for Cancer Research | - |
dc.rights | © 2015 American Association for Cancer Research | - |
dc.source.uri | http://dx.doi.org/10.1158/1055-9965.epi-14-1161 | - |
dc.subject | Humans | - |
dc.subject | Colorectal Neoplasms | - |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Risk Factors | - |
dc.subject | DNA Methylation | - |
dc.subject | CpG Islands | - |
dc.subject | Phenotype | - |
dc.subject | Middle Aged | - |
dc.subject | Family Health | - |
dc.title | Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-14-1161 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Young, J. [0000-0002-1514-1522] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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