Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/102585
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Type: Journal article
Title: Naturally derived iron oxide nanowires from bacteria for magnetically triggered drug release and cancer hyperthermia in 2D and 3D culture environments: bacteria Bbiofilm to potent cancer therapeutic
Author: Kumeria, T.
Maher, S.
Wang, Y.
Kaur, G.
Wang, L.
Erkelens, M.
Forward, P.
Lambert, M.
Evdokiou, A.
Losic, D.
Citation: Biomacromolecules, 2016; 17(8):2726-2736
Publisher: American Chemical Society
Issue Date: 2016
ISSN: 1525-7797
1526-4602
Statement of
Responsibility: 
Tushar Kumeria, Shaheer Maher, Ye Wang, Gagandeep Kaur, Luoshan Wang, Mason Erkelens, Peter Forward, Martin F. Lambert, Andreas Evdokiou, and Dusan Losic
Abstract: Iron oxide nanowires produced by bacteria (Mariprofundus ferrooxydans) are demonstrated as new multifunctional drug carriers for triggered therapeutics release and cancer hyperthmia applications. Iron oxide nanowires are obtained from biofilm waste in the bore system used to pump saline groundwater into the River Murray, South Australia (Australia) and processed into individual nanowires with extensive magnetic properties. The drug carrier capabilities of these iron oxide nanowires (Bac-FeOxNWs) are assessed by loading anticancer drug (doxorubicin, Dox) followed by measuring its elution under sustained and triggered release conditions using alternating magnetic field (AMF). The cytotoxicity of Bac-FeOxNWs assessed in 2D (96 well plate) and 3D (Matrigel) cell cultures using MDA-MB231-TXSA human breast cancer cells and mouse RAW 264.7 macrophage cells shows that these Bac-FeOxNWs are biocompatible even at concentrations as high as 250 μg/mL after 24 h of incubation. Finally, we demonstrate the capabilities of Bac-FeOxNWs as potential hyperthermia agent in 3D culture setup. Application of AMF increased the local temperature by 14 °C resulting in approximately 34% decrease in cell viability. Our results demonstrate that these naturally produced nanowires in the form of biofilm can efficiently act as drug carriers with triggered payload release and magnetothermal heating features for potential anticancer therapeutics applications.
Keywords: Cells, Cultured; Macrophages; Animals; Humans; Mice; Bacteria; Biofilms; Breast Neoplasms; Fever; Ferric Compounds; Doxorubicin; Antibiotics, Antineoplastic; Drug Carriers; Combined Modality Therapy; Cell Culture Techniques; Cell Survival; Magnetics; Female; Nanowires; Drug Liberation
Rights: © 2016 American Chemical Society
RMID: 0030052438
DOI: 10.1021/acs.biomac.6b00786
Grant ID: http://purl.org/au-research/grants/arc/DP120101680
http://purl.org/au-research/grants/arc/FT110100711
http://purl.org/au-research/grants/arc/DE140100549
Published version: http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00786
Appears in Collections:Chemical Engineering publications

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