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Type: Journal article
Title: Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation
Author: Holmes-Liew, C.
Holmes, M.
Beagley, L.
Hopkins, P.
Chambers, D.
Smith, C.
Khanna, R.
Citation: Clinical & translational immunology, 2015; 4(3):e35-1-e35-5
Publisher: Nature
Issue Date: 2015
ISSN: 2050-0068
Statement of
Chien-Li Holmes-Liew, Mark Holmes, Leone Beagley, Peter Hopkins, Daniel Chambers Corey Smith and Rajiv Khanna
Abstract: Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir-resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV-specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus-specific T-cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV-specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir-resistant CMV disease, resulting in the long-term reconstitution of protective anti-viral immunity, CMV infection, disease-free survival and no allograft rejection.
Rights: © 2015 Australasian Society for Immunology Inc. All rights reserved 2050-0068/15. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, userswill need to obtain permission fromthe license holder to reproduce the material. To view a copy of this license, visit http://
RMID: 0030039158
DOI: 10.1038/cti.2015.5
Appears in Collections:Medicine publications

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