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https://hdl.handle.net/2440/103590
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Type: | Journal article |
Title: | Silver coating for high-mass-accuracy imaging mass spectrometry of fingerprints on nanostructured silicon |
Author: | Guinan, T. Gustafsson, O. McPhee, G. Kobus, H. Voelcker, N. |
Citation: | Analytical Chemistry, 2015; 87(22):11195-11202 |
Publisher: | American Chemical Society |
Issue Date: | 2015 |
ISSN: | 0003-2700 1520-6882 |
Statement of Responsibility: | Taryn M. Guinan, Ove J. R. Gustafsson, Gordon McPhee, Hilton Kobus, and Nicolas H. Voelcker |
Abstract: | Nanostructure imaging mass spectrometry (NIMS) using porous silicon (pSi) is a key technique for molecular imaging of exogenous and endogenous low molecular weight compounds from fingerprints. However, high-mass-accuracy NIMS can be difficult to achieve as time-of-flight (ToF) mass analyzers, which dominate the field, cannot sufficiently compensate for shifts in measured m/z values. Here, we show internal recalibration using a thin layer of silver (Ag) sputter-coated onto functionalized pSi substrates. NIMS peaks for several previously reported fingerprint components were selected and mass accuracy was compared to theoretical values. Mass accuracy was improved by more than an order of magnitude in several cases. This straightforward method should form part of the standard guidelines for NIMS studies for spatial characterization of small molecules. |
Keywords: | Mass Spectrometry; silicon; nanoparticles; molecular imaging |
Rights: | © 2015 American Chemical Society |
DOI: | 10.1021/acs.analchem.5b02567 |
Grant ID: | http://purl.org/au-research/grants/arc/CE140100036 http://purl.org/au-research/grants/arc/LP110200446 |
Published version: | http://dx.doi.org/10.1021/acs.analchem.5b02567 |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
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