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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/104933
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dc.contributor.authorChen, M.M.-
dc.contributor.authorO'Mara, T.A.-
dc.contributor.authorThompson, D.J.-
dc.contributor.authorPainter, J.N.-
dc.contributor.authorAttia, J.-
dc.contributor.authorBlack, A.-
dc.contributor.authorBrinton, L.-
dc.contributor.authorChanock, S.-
dc.contributor.authorChen, C.-
dc.contributor.authorCheng, T.H.-
dc.contributor.authorCook, L.S.-
dc.contributor.authorCrous-Bou, M.-
dc.contributor.authorDoherty, J.-
dc.contributor.authorFriedenreich, C.M.-
dc.contributor.authorGarcia-Closas, M.-
dc.contributor.authorGaudet, M.M.-
dc.contributor.authorGorman, M.-
dc.contributor.authorHaiman, C.-
dc.contributor.authorHankinson, S.E.-
dc.contributor.authorHartge, P.-
dc.contributor.authoret al.-
dc.date.issued2016-
dc.identifier.citationHuman Molecular Genetics, 2016; 25(12):2612-2620-
dc.identifier.issn0964-6906-
dc.identifier.issn1460-2083-
dc.identifier.urihttp://hdl.handle.net/2440/104933-
dc.description.abstractEndometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.-
dc.description.statementofresponsibilityMaxine M. Chen, Tracy A. O'Mara, Deborah J. Thompson, Jodie N. Painter, John Attia … Joanne Young … et al. (The Australian National Endometrial Cancer Study Group and National Study Of Endometrial Cancer Genetics Group)-
dc.language.isoen-
dc.publisherOxford University Press-
dc.rights© The Author 2016. Published by Oxford University Press. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1093/hmg/ddw092-
dc.subjectEndometrial cancer; genetic predisposition to disease; genome; single nucleotide polymorphism; gynecologic cancer; genetic risk; genome-wide association study-
dc.titleGWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer-
dc.typeJournal article-
dc.identifier.doi10.1093/hmg/ddw092-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/339435-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/552402-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1031333-
pubs.publication-statusPublished-
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Medicine publications

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