Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/107163
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Churchman, M. | - |
dc.contributor.author | Low, J. | - |
dc.contributor.author | Qu, C. | - |
dc.contributor.author | Paietta, E. | - |
dc.contributor.author | Kasper, L. | - |
dc.contributor.author | Chang, Y. | - |
dc.contributor.author | Payne-Turner, D. | - |
dc.contributor.author | Althoff, M. | - |
dc.contributor.author | Song, G. | - |
dc.contributor.author | Chen, S.-C. | - |
dc.contributor.author | Ma, J. | - |
dc.contributor.author | Rusch, M. | - |
dc.contributor.author | McGoldrick, D. | - |
dc.contributor.author | Edmonson, M. | - |
dc.contributor.author | Gupta, P. | - |
dc.contributor.author | Wang, Y.-D. | - |
dc.contributor.author | Caufield, W. | - |
dc.contributor.author | Freeman, B. | - |
dc.contributor.author | Li, L. | - |
dc.contributor.author | Panetta, J. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Cancer Cell, 2015; 28(3):343-356 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.issn | 1878-3686 | - |
dc.identifier.uri | http://hdl.handle.net/2440/107163 | - |
dc.description.abstract | Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations synergistically promote the development of an aggressive lymphoid leukemia. Ikzf1 alterations result in acquisition of stem cell-like features, including self-renewal and increased bone marrow stromal adhesion. Retinoid receptor agonists reversed this phenotype, partly by inducing expression of IKZF1, resulting in abrogation of adhesion and self-renewal, cell cycle arrest, and attenuation of proliferation without direct cytotoxicity. Retinoids potentiated the activity of dasatinib in mouse and human BCR-ABL1 ALL, providing an additional therapeutic option in IKZF1-mutated ALL. | - |
dc.description.statementofresponsibility | Michelle L. Churchman, Jonathan Low, Chunxu Qu, Elisabeth M. Paietta, Lawryn H. Kasper ... Charles G. Mullighan ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | Copyright © 2015 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ccell.2015.07.016 | - |
dc.subject | Fusion Proteins, bcr-abl | - |
dc.title | Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ccell.2015.07.016 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mullighan, C. [0000-0002-1871-1850] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.