Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113413
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Type: | Journal article |
Title: | Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice |
Author: | Xie, V. Tong, D. Wallington-Beddoe, C.T. Bradstock, K.F. Bendall, L.J. |
Citation: | Biomarker Research, 2018; 6(6):1-7 |
Publisher: | BioMed Central |
Issue Date: | 2018 |
ISSN: | 2050-7771 2050-7771 |
Statement of Responsibility: | Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendall |
Abstract: | Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL).In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF.Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2.These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of this enzyme to ALL patients whose disease have driver mutations other than BCR/ABL1. |
Keywords: | Acute lymphoblastic leukemia Mouse models Sphingosine kinase 2 |
Rights: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
DOI: | 10.1186/s40364-018-0120-4 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1042305 |
Published version: | http://dx.doi.org/10.1186/s40364-018-0120-4 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_113413.pdf | Published Version | 2.46 MB | Adobe PDF | View/Open |
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