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Type: Journal article
Title: Glycointeractions in bacterial pathogenesis
Author: Poole, J.
Day, C.
Von Itzstein, M.
Paton, J.
Jennings, M.
Citation: Nature Reviews Microbiology, 2018; 16(7):440-452
Publisher: Nature Publishing Group
Issue Date: 2018
ISSN: 1740-1526
Statement of
Jessica Poole, Christopher J. Day, Mark von Itzstein, James C. Paton and Michael P. Jennings
Abstract: Many important interactions between bacterial pathogens and their hosts are highly specific binding events that involve host or pathogen carbohydrate structures (glycans). Glycan interactions can mediate adhesion, invasion and immune evasion and can act as receptors for toxins. Several bacterial pathogens can also enzymatically alter host glycans to reveal binding targets, degrade the host cell glycans or alter the function of host glycoproteins. In recent years, high-throughput screening technologies, such as lectin, glycan and mucin microarrays, have transformed the field by identifying new bacterial-host glycointeractions, which are crucial for colonization, persistence and disease. In this Review, we discuss interactions involving both host and bacterial glycans that have a role in bacterial pathogenesis. We also highlight recent technological advances that have illuminated the glycoscience of microbial pathogenesis.
Description: Published online 19 April 2018
Rights: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
RMID: 0030085927
DOI: 10.1038/s41579-018-0007-2
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Appears in Collections:Molecular and Biomedical Science publications

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