Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: The Late-Expressed Region of the Temperate Coliphage 186 Genome
Author: Portelli, R.
Dodd, I.
Xue, Q.
Egan, J.
Citation: Virology, 1998; 248(1):117-130
Issue Date: 1998
ISSN: 0042-6822
Statement of
Roberto Portelli, Ian B. Dodd, Qing Xue and J. Barry Egan
Abstract: The late-lytic region of the genome of bacteriophage 186 encodes the phage proteins that synthesize the complex viral particle and lyse the bacterial host. We report the completion of the DNA sequence of the late region and the assignment of 18 previously identified genes to open reading frames in the sequence. The 186 late region is similar to the late region of phage P2, sharing 26 genes of known function: the single gene for activation of late gene transcription, 6 genes for construction of DNA-containing heads, 16 for tail morphogenesis, and 3 for cell lysis. We identified two 186 late genes with unknown function; one is homologous to previously unrecognised genes in P2, HP1, and fCTX, and the other may modulate DNA packaging. The 186 late region, like the rest of the genome, lacks the lysogenic conversion genes that are carried by P2, allowing the 186 late region to be transcribed from only three late promoters rather than four. The relative absence of lysogenic conversion genes in 186 suggests that the two phages have evolved to use the lytic and lysogenic reproductive modes to different extents.
Keywords: Escherichia coli
Bacteriophage P2
Viral Proteins
DNA, Viral
Sequence Alignment
Amino Acid Sequence
Base Sequence
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Genes, Viral
Genome, Viral
Open Reading Frames
Molecular Sequence Data
Promoter Regions, Genetic
Description: Copyright 1998 Academic Press
DOI: 10.1006/viro.1998.9263
Published version:
Appears in Collections:Aurora harvest 7
Biochemistry publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.