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https://hdl.handle.net/2440/114135
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Type: | Journal article |
Title: | TGF- α overexpression in breast cancer bone metastasis and primary lesions and TGF- α enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells |
Other Titles: | TGF- alpha overexpression in breast cancer bone metastasis and primary lesions and TGF- alpha enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells |
Author: | Sun, J. Cui, H. Gao, Y. Pan, Y. Zhou, K. Huang, J. Lan, J. Wei, Q. Liu, X. Liu, L. Xian, C.J. |
Citation: | BioMed Research International, 2018; 2018:6565393-1-6565393-10 |
Publisher: | Hindawi Publishing |
Issue Date: | 2018 |
ISSN: | 2314-6133 2314-6141 |
Statement of Responsibility: | Jingbo Sun, Haiyan Cui, Yanxin Gao, Yangjian Pan, Kun Zhou, Jingzhan Huang, Jin Lan, Qingzhu Wei, Xiaolong Liu, Lixin Liu and Cory J. Xian |
Abstract: | Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in the microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles of transforming growth factor- (TGF-) α in the interaction between breast cancer and BMSCs in BM. Clinical cases of breast cancer with bone metastasis (BMBC), breast cancer without bone metastasis (Non-BM-BC), and benign fibroadenoma (Benign) were enlisted in a retrospective study. TGF-α was found obviously overexpressed in BM lesion of BMBC compared to primary lesion of both BMBC and Non-BM-BC (), and TGF-α was higher in primary lesion of both BMBC and Non-BM-BC () than Benign group. Interestingly, TGF-α in nontumor tissues of both BMBC and Non-BM-BC was at a higher level than Benign group (), and numbers of macrophages in nontumor tissues of both BMBC and Non-BM-BC () were higher than Benign group. Furthermore, in cultured human BMSCs, TGF-α stimulated production of procancer cytokines including IL-6, VEGF, FGF10, FGF17, and TGF-β1 in a dose-dependent manner. Thus, TGF-α in BC could potentially be an important signal of carcinogenesis and metastasis. Macrophages in the nontumor tissue of BC may not be protective but could promote cancer metastasis. |
Keywords: | Bone Marrow Cells Mesenchymal Stem Cells Humans Bone Neoplasms Breast Neoplasms Neoplasm Metastasis Transforming Growth Factor alpha Neoplasm Proteins Cytokines Aged Middle Aged Female |
Rights: | © 2018 Jingbo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1155/2018/6565393 |
Grant ID: | 201604KW011 http://purl.org/au-research/grants/nhmrc/1042105 |
Published version: | http://dx.doi.org/10.1155/2018/6565393 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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File | Description | Size | Format | |
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hdl_114135.pdf | Published Version | 7.96 MB | Adobe PDF | View/Open |
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