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https://hdl.handle.net/2440/114155
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Type: | Journal article |
Title: | Anxiety, depression and fatigue at 5-year review following CNS demyelination |
Author: | Simpson, S. Tan, H. Otahal, P. Taylor, B.V. Ponsonby, A.L. Lucas, R.M. Blizzard, L. Valery, P.C. Lechner-Scott, J. Shaw, C. Williams, D. van der Mei, I. |
Citation: | Acta Neurologica Scandinavica, 2016; 134(6):403-413 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 0001-6314 1600-0404 |
Statement of Responsibility: | S. Simpson, H. Tan, P. Otahal, B. Taylor, A.-L. Ponsonby, R.M. Lucas, L. Blizzard, P.C. Valery, J. Lechner-Scott, C. Shaw, D. Williams, Ausimmune/AusLong Investigators Group, I. van der Mei, Keith Dear |
Abstract: | Background - Anxiety and depression are common in multiple sclerosis (MS). We evaluated the prevalence and factors associated with anxiety, depression and fatigue at the 5-year review of a longitudinal cohort study following a first clinical diagnosis of CNS demyelination (FCD). Methods - Cases with a FCD were recruited soon after diagnosis and followed annually thereafter. A variety of environmental, behavioural and clinical covariates were measured at five-year review. Anxiety and depression were measured using the Hospital Anxiety & Depression Scale (HADS), and fatigue by the Fatigue Severity Scale (FSS). Results - Of the 236 cases, 40.2% had clinical anxiety (median HADSA: 6.0), 16.0% had clinical depression (median HADS-D: 3.0), and 41.3% had clinical fatigue (median FSS: 4.56). The co-occurrence of all three symptoms was 3.76 times greater than expectation. Younger age, higher disability, concussion or other disease diagnosis were independently associated with a higher anxiety score; male sex, higher disability, being unemployed, less physical activity, and antidepressant and/or anxiolytic-sedative medication use were independently associated with a higher depression score. Higher disability, immunomodulatory medication use, other disease diagnosis and anxiolytic-sedative medication use were independently associated with having fatigue, while female sex, higher BMI, having had a concussion, being unemployed and higher disability were associated with a higher fatigue score. Conclusion - These results support previous findings of the commonality of anxiety, depression and fatigue in established MS and extend this to post-FCD and early MS cases. The clustering of the three symptoms indicates that they may share common antecedents. |
Keywords: | Multiple sclerosis; prevalence; anxiety; depression; fatigue; first demyelinating event |
Rights: | © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
DOI: | 10.1111/ane.12554 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/316901 http://purl.org/au-research/grants/nhmrc/224215 http://purl.org/au-research/grants/nhmrc/1083090 ARC |
Published version: | http://dx.doi.org/10.1111/ane.12554 |
Appears in Collections: | Aurora harvest 8 Public Health publications |
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