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Type: Journal article
Title: Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity
Author: Neumann, D.
Goodall, G.
Gregory, P.
Citation: Seminars in Cell and Developmental Biology, 2018; 75:50-60
Publisher: Elsevier
Issue Date: 2018
ISSN: 1084-9521
Statement of
Daniel P.Neumann, Gregory J.Goodall, Philip A.Gregory
Abstract: Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes.
Keywords: Alternative splicing; Circular RNA; Epithelial-mesenchymal transition
Rights: © 2017 Elsevier Ltd. All rights reserved.
RMID: 0030075386
DOI: 10.1016/j.semcdb.2017.08.008
Grant ID:
Appears in Collections:Molecular and Biomedical Science publications

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