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https://hdl.handle.net/2440/114312
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Type: | Journal article |
Title: | A randomised controlled trial of perineural vs intravenous dexamethasone for foot surgery |
Author: | Dawson, R. Mcleod, D. Koerber, J. Plummer, J. Dracopoulos, G. |
Citation: | Anaesthesia, 2016; 71(3):285-290 |
Publisher: | Wiley-Blackwell |
Issue Date: | 2016 |
ISSN: | 0003-2409 1365-2044 |
Statement of Responsibility: | R. L. Dawson, D. H. McLeod, J. P. Koerber, J. L. Plummer, G. C. Dracopoulos |
Abstract: | We used 20 ml ropivacaine 0.75% for ankle blocks before foot surgery in 90 participants who we allocated in equal numbers to: perineural dexamethasone 8 mg and intravenous saline 0.9%; perineural saline 0.9% and intravenous dexamethasone 8 mg; or perineural and intravenous saline 0.9%. Dexamethasone increased the median (IQR [range]) time for the return of some sensation or movement, from 14.6 (10.8-18.8 [5.5-38.0]) h with saline to 24.1 (19.3-29.3 [5.0-44.0]) h when given perineurally, p = 0.00098, and to 20.9 (18.3-27.8 [8.8-31.3]) h when given intravenously, p = 0.0067. Dexamethasone increased the median (IQR [range]) time for the return of normal neurology, from 17.6 (14.0-21.0 [9.5-40.5]) h with saline to 27.5 (22.0-36.3 [7.0-53.0]) h when given perineurally, p = 0.00016, and to 24.0 (20.5-32.3 [13.0-42.5]) h when given intravenously, p = 0.0022. Dexamethasone did not affect the rates of block success, postoperative pain scores, analgesic use, or nausea and vomiting. The route of dexamethasone administration did not alter its effects. |
Keywords: | Foot Humans Pain, Postoperative Sodium Chloride Amides Dexamethasone Anesthetics, Local Glucocorticoids Anesthesia Recovery Period Time Factors Adult Aged Aged, 80 and over Middle Aged Female Male Ropivacaine |
Rights: | © 2015 The Association of Anaesthetists of Great Britain and Ireland |
DOI: | 10.1111/anae.13346 |
Published version: | http://dx.doi.org/10.1111/anae.13346 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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