Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114887
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Type: Journal article
Title: Developing a dementia-specific preference-based quality of life measure (AD-5D) in Australia: a valuation study protocol
Author: Comans, T.
Nguyen, K.
Mulhern, B.
Corlis, M.
Li, L.
Welch, A.
Kurrle, S.
Rowen, D.
Moyle, W.
Kularatna, S.
Ratcliffe, J.
Citation: BMJ Open, 2018; 8(1):e018996-1-e018996-7
Publisher: BMJ Journals
Issue Date: 2018
ISSN: 2044-6055
2044-6055
Statement of
Responsibility: 
Tracy A Comans, Kim-Huong Nguyen, Brendan Mulhern, Megan Corlis, Li Li, Alyssa Welch, Susan E Kurrle, Donna Rowen, Wendy Moyle, Sanjeewa Kularatna, Julie Ratcliffe
Abstract: Introduction: Generic instruments for assessing health-related quality of life may lack the sensitivity to detect changes in health specific to certain conditions, such as dementia. The Quality of Life in Alzheimer’s Disease (QOL-AD) is a widely used and well-validated condition-specific instrument for assessing health-related quality of life for people living with dementia, but it does not enable the calculation of quality-adjusted life years, the basis of cost utility analysis. This study will generate a preference-based scoring algorithm for a health state classification system -the Alzheimer’s Disease Five Dimensions (AD-5D) derived from the QOL-AD. Methods and analysis: Discrete choice experiments with duration (DCETTO) and best–worst scaling health state valuation tasks will be administered to a representative sample of 2000 members of the Australian general population via an online survey and to 250 dementia dyads (250 people with dementia and their carers) via face-to-face interview. A multinomial (conditional) logistic framework will be used to analyse responses and produce the utility algorithm for the AD-5D. Ethics and dissemination: The algorithms developed will enable prospective and retrospective economic evaluation of any treatment or intervention targeting people with dementia where the QOL-AD has been administered and will be available online. Results will be disseminated through journals that publish health economics articles and through professional conferences. This study has ethical approval.
Keywords: Humans; Alzheimer Disease; Logistic Models; Retrospective Studies; Prospective Studies; Psychiatric Status Rating Scales; Psychometrics; Quality-Adjusted Life Years; Research Design; Quality of Life; Caregivers; Cost-Benefit Analysis; Australia; Surveys and Questionnaires
Rights: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Open Access. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
RMID: 0030098629
DOI: 10.1136/bmjopen-2017-018996
Grant ID: http://purl.org/au-research/grants/nhmrc/9100000
Appears in Collections:Public Health publications

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