Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114949
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Type: Journal article
Title: Laboratory diagnosis of Mycoplasma pneumoniae infection: 3. Detection of IgM antibodies to M. pneumoniae by a modified indirect haemagglutination test
Author: Kok, T.
Marmion, B.
Varkanis, G.
Worswick, D.
Martin, J.
Citation: Epidemiology and Infection, 1989; 103(3):613-623
Publisher: Cambridge University Press
Issue Date: 1989
ISSN: 0950-2688
1469-4409
Statement of
Responsibility: 
T.-W. Kok, B. P. Marmion, G. Varkanis, D. A. Worswick and J. Martin
Abstract: The indirect haemagglutination (IHA) test was compared with the complement-fixation (CF) test for the measurement of antibodies to Mycoplasma pneumoniae. A modification of the IHA was used to measure M. pneumoniae IgM antibodies. Sera were obtained from various groups of patients who were either culture or antigen positive for M. pneumoniae in nasopharyngeal aspirates or who had fourfold or greater increase in CF antibody or a titre greater than or equal to 320. The results of these comparisons showed that the modified IHA test was specific and more sensitive (89% as opposed to 64%) than the CF test. The modified IHA test for the detection of IgM antibody was highly effective in the recognition of recent or current infection with the mycoplasma. It was also of equal sensitivity to an indirect enzyme immunoassay for the detection of IgM antibodies to M. pneumoniae.
Keywords: Mycoplasma pneumoniae; Immunoglobulin M; Antibodies, Bacterial
Rights: © Cambridge University Press 1989
RMID: 0030075259
DOI: 10.1017/S0950268800031010
Appears in Collections:Medicine publications

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