Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/116950
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Type: Journal article
Title: Obesity-Associated alterations in glucose metabolism are reversed by chronic bilateral stimulation of the abdominal vagus nerve
Author: Malbert, C.
Picq, C.
Divoux, J.
Henry, C.
Horowitz, M.
Citation: Diabetes, 2017; 66(4):848-857
Publisher: American Diabetes Association
Issue Date: 2017
ISSN: 0012-1797
1939-327X
Statement of
Responsibility: 
Charles-Henri Malbert, Chloé Picq, Jean-Louis Divoux, Christine Henry and Michael Horowitz
Abstract: Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral vagal stimulation is not known. Our aim was to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after permanent, bilateral, vagal stimulation performed at the abdominal level in adult mini-pigs. In 15 adult mini-pigs, stimulating electrodes were placed around the dorsal and ventral vagi using laparoscopy and connected to a dual-channel stimulator placed subcutaneously. Animals were divided into three groups based on stimulation and body weight (i.e., lean nonstimulated, obese nonstimulated, and obese stimulated). Twelve weeks after surgery, glucose uptake and insulin sensitivity were measured using positron emission tomography during an isoglycemic clamp. Mean whole-body insulin sensitivity was lower by 34% (P < 0.01) and the hepatic glucose uptake rate was lower by 33% (P < 0.01) in obese-nonstimulated mini-pigs but was no different in obese-stimulated compared with lean mini-pigs. An improvement in skeletal glucose uptake rate was also observed in obese-stimulated compared with obese-nonstimulated groups (P < 0.01). Vagal stimulation was associated with increased glucose metabolism in the cingulate and prefrontal brain areas. We conclude that chronic vagal stimulation improves insulin sensitivity substantially in diet-induced obesity by both peripheral and central mechanisms.
Keywords: Muscle, Skeletal
Rights: © 2017 by the American Diabetes Association.
RMID: 0030062436
DOI: 10.2337/db16-0847
Appears in Collections:Medicine publications

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