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https://hdl.handle.net/2440/120430
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Type: | Journal article |
Title: | Two new spiro-heterocyclic γ-lactams from a marine-derived Aspergillus fumigatus strain CUGBMF170049 |
Other Titles: | Two new spiro-heterocyclic gamma-lactams from a marine-derived Aspergillus fumigatus strain CUGBMF170049 |
Author: | Xu, X. Han, J. Wang, Y. Lin, R. Yang, H. Li, J. Wei, S. Polyak, S.W. Song, F. |
Citation: | Marine Drugs, 2019; 17(5):289-1-289-8 |
Publisher: | MDPI |
Issue Date: | 2019 |
ISSN: | 1660-3397 1660-3397 |
Statement of Responsibility: | Xiuli Xu, Jiahui Han, Yanan Wang, Rui Lin, Haijin Yang, Jiangpeng Li, Shangzhu Wei, Steven W. Polyak, and Fuhang Song |
Abstract: | Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. |
Keywords: | Marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins |
Rights: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/md17050289 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1147538 |
Published version: | http://dx.doi.org/10.3390/md17050289 |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
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