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https://hdl.handle.net/2440/120833
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dc.contributor.author | Watson, L.E. | - |
dc.contributor.author | Phillips, L.K. | - |
dc.contributor.author | Wu, T. | - |
dc.contributor.author | Bound, M.J. | - |
dc.contributor.author | Jones, K.L. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C.K. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Diabetes Research and Clinical Practice, 2019; 154:27-34 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120833 | - |
dc.description.abstract | Aims: To evaluate the natural history of gastric emptying in type 2 diabetes. Methods: 12 patients with type 2 diabetes (7 female; age 65.6 ± 1.2 years; duration of known diabetes 22.9 ± 1.5 years) were invited to return for repeat measurements of gastric emptying using the same dual-labelled solid and liquid meal, a mean of 14.0±0.5 years after their initial study. Blood glucose levels, glycated haemoglobin, upper gastrointestinal symptoms and autonomic nerve function at baseline and follow up were also compared. Results: Gastric emptying of solids was more rapid at follow up than at baseline (period effect P<0.05), while emptying of liquids was comparable at baseline and follow up (period effect P=0.2). Gastric emptying of the solid component was abnormally slow (based on T100min) in 6 subjects at baseline and 1 subject at follow up. Liquid emptying was abnormally slow in 6 subjects at baseline, and 5 subjects at follow up. Two patients were insulin treated at baseline, and 6 at follow up. HbA1c was higher at follow up (P<0.05); however, fasting blood glucose (P=0.6), postprandial blood glucose excursions (P=0.07), autonomic nerve function (P>0.999), and total upper gastrointestinal symptom score (P=0.1) did not differ. Conclusions: In patients with long-term type 2 diabetes, gastric emptying of solids and liquids does not usually become more delayed over time, and abnormally slow gastric emptying of solids may improve. | - |
dc.description.statementofresponsibility | Linda E. Watson, Liza K. Phillips, Tongzhi Wu, Michelle J. Bound, Karen L. Jones, Michael Horowitz, Christopher K. Rayner | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2019 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.diabres.2019.06.010 | - |
dc.subject | Gastric emptying; type 2 diabetes; longitudinal; scintigraphy | - |
dc.title | Longitudinal evaluation of gastric emptying in type 2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.diabres.2019.06.010 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1066815 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Phillips, L.K. [0000-0002-9066-717X] | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
dc.identifier.orcid | Bound, M.J. [0000-0003-0211-5832] | - |
dc.identifier.orcid | Jones, K.L. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C.K. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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