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https://hdl.handle.net/2440/123830
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dc.contributor.author | Voskoboinik, A. | - |
dc.contributor.author | Kalman, J.M. | - |
dc.contributor.author | Silva, A.D. | - |
dc.contributor.author | Nicholls, T. | - |
dc.contributor.author | Costello, B. | - |
dc.contributor.author | Nanayakkara, S. | - |
dc.contributor.author | Prabhu, S. | - |
dc.contributor.author | Stub, D. | - |
dc.contributor.author | Azzopardi, S. | - |
dc.contributor.author | Vizi, D. | - |
dc.contributor.author | Wong, G. | - |
dc.contributor.author | Nalliah, C. | - |
dc.contributor.author | Sugumar, H. | - |
dc.contributor.author | Wong, M. | - |
dc.contributor.author | Kotschet, E. | - |
dc.contributor.author | Kaye, D. | - |
dc.contributor.author | Taylor, A.J. | - |
dc.contributor.author | Kistler, P.M. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | New England Journal of Medicine, 2020; 382(1):20-28 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.issn | 1533-4406 | - |
dc.identifier.uri | http://hdl.handle.net/2440/123830 | - |
dc.description.abstract | BACKGROUND:Excessive alcohol consumption is associated with incident atrial fibrillation and adverse atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atrial fibrillation is unclear. METHODS:We conducted a multicenter, prospective, open-label, randomized, controlled trial at six hospitals in Australia. Adults who consumed 10 or more standard drinks (with 1 standard drink containing approximately 12 g of pure alcohol) per week and who had paroxysmal or persistent atrial fibrillation in sinus rhythm at baseline were randomly assigned in a 1:1 ratio to either abstain from alcohol or continue their usual alcohol consumption. The two primary end points were freedom from recurrence of atrial fibrillation (after a 2-week "blanking period") and total atrial fibrillation burden (proportion of time in atrial fibrillation) during 6 months of follow-up. RESULTS:Of 140 patients who underwent randomization (85% men; mean [±SD] age, 62±9 years), 70 were assigned to the abstinence group and 70 to the control group. Patients in the abstinence group reduced their alcohol intake from 16.8±7.7 to 2.1±3.7 standard drinks per week (a reduction of 87.5%), and patients in the control group reduced their alcohol intake from 16.4±6.9 to 13.2±6.5 drinks per week (a reduction of 19.5%). After a 2-week blanking period, atrial fibrillation recurred in 37 of 70 patients (53%) in the abstinence group and in 51 of 70 patients (73%) in the control group. The abstinence group had a longer period before recurrence of atrial fibrillation than the control group (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; P = 0.005). The atrial fibrillation burden over 6 months of follow-up was significantly lower in the abstinence group than in the control group (median percentage of time in atrial fibrillation, 0.5% [interquartile range, 0.0 to 3.0] vs. 1.2% [interquartile range, 0.0 to 10.3]; P = 0.01). CONCLUSIONS:Abstinence from alcohol reduced arrhythmia recurrences in regular drinkers with atrial fibrillation. (Funded by the Government of Victoria Operational Infrastructure Support Program and others; Australian New Zealand Clinical Trials Registry number, ACTRN12616000256471.). | - |
dc.description.statementofresponsibility | Aleksandr Voskoboinik, Jonathan M. Kalman, Anurika De Silva, Thomas Nicholls, Benedict Costello ... Geoffrey Wong ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Massachusetts Medical Society | - |
dc.rights | © 2020 Massachusetts Medical Society. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1056/nejmoa1817591 | - |
dc.subject | Humans | - |
dc.subject | Atrial Fibrillation | - |
dc.subject | Risk Factors | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Prospective Studies | - |
dc.subject | Alcohol Drinking | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Secondary Prevention | - |
dc.subject | Alcohol Abstinence | - |
dc.title | Alcohol abstinence in drinkers with atrial fibrillation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1056/NEJMoa1817591 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/101098 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wong, G. [0000-0002-9733-7712] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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