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https://hdl.handle.net/2440/129734
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Type: | Journal article |
Title: | Manganese import protects Salmonella enterica serovar Typhimurium against nitrosative stress |
Author: | Yousuf, S. Karlinsey, J.E. Neville, S.L. McDevitt, C.A. Libby, S.J. Fang, F.C. Frawley, E.R. |
Citation: | Metallomics: integrated biometal science, 2020; 12(11):1791-1801 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2020 |
ISSN: | 1756-5901 1756-591X |
Statement of Responsibility: | Shehla Yousuf, Joyce E. Karlinsey, Stephanie L. Neville, Christopher A. McDevitt, Stephen J. Libby, Ferric C. Fang and Elaine R. Frawley |
Abstract: | Nitric oxide (NO•) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial pathogens. It exerts its antimicrobial activity in part by impairing the function of metalloproteins, particularly those containing iron and zinc cofactors. The pathogenic Gram-negative bacterium Salmonella enterica serovar typhimurium undergoes dynamic changes in its cellular content of the four most common metal cofactors following exposure to NO• stress. Zinc, iron and magnesium all decrease in response to NO• while cellular manganese increases significantly. Manganese acquisition is driven primarily by increased expression of the mntH and sitABCD transporters following derepression of MntR and Fur. ZupT also contributes to manganese acquisition in response to nitrosative stress. S. Typhimurium mutants lacking manganese importers are more sensitive to NO•, indicating that manganese is important for resistance to nitrosative stress. |
Keywords: | Salmonella typhimurium Magnesium Iron Manganese Nitric Oxide Bacterial Proteins Cation Transport Proteins Colony Count, Microbial Gene Expression Regulation, Bacterial Up-Regulation Biological Transport Mutation Microbial Viability Nitrosative Stress |
Rights: | This journal is © The Royal Society of Chemistry 2020 |
DOI: | 10.1039/d0mt00178c |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1140554 http://purl.org/au-research/grants/nhmrc/1180826 http://purl.org/au-research/grants/nhmrc/1142695 http://purl.org/au-research/grants/arc/FT170100006 |
Published version: | http://dx.doi.org/10.1039/d0mt00178c |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
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