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https://hdl.handle.net/2440/130147
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dc.contributor.author | Elovaris, R.A. | - |
dc.contributor.author | Hajishafiee, M. | - |
dc.contributor.author | Ullrich, S.S. | - |
dc.contributor.author | Ce Fitzgerald, P. | - |
dc.contributor.author | Lange, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Diabetes Research and Clinical Practice, 2021; 171:1-8 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | http://hdl.handle.net/2440/130147 | - |
dc.description.abstract | AIMS: In healthy individuals, intragastric administration of the branched-chain amino acids, leucine and isoleucine, diminishes the glycaemic response to a mixed-nutrient drink, apparently by stimulating insulin and slowing gastric emptying, respectively. This study aimed to evaluate the effects of leucine and isoleucine on postprandial glycaemia and gastric emptying in type-2 diabetes mellitus (T2D). METHODS: 14 males with T2D received, on 3 separate occasions, in double-blind, randomised fashion, either 10g leucine, 10g isoleucine or control, intragastrically 30 min before a mixed-nutrient drink (500 kcal; 74g carbohydrates, 18g protein, 15g fat). Plasma glucose, insulin and glucagon were measured from 30 min pre- until 120 min post-drink. Gastric emptying of the drink was also measured. RESULTS: Leucine and isoleucine stimulated insulin, both before and after the drink (all P<0.05; peak (mU/L): control: 70±15; leucine: 88±17; isoleucine: 74±15). Isoleucine stimulated (P<0.05), and leucine tended to stimulate (P=0.078), glucagon before the drink, and isoleucine stimulated glucagon post-drink (P=0.031; peak (pg/mL): control: 62±5; leucine: 70±9; isoleucine: 69±6). Neither amino acid affected gastric emptying or plasma glucose (peak (mmol/L): control: 12.0±0.5; leucine: 12.5±0.7; isoleucine: 12.0±0.6). CONCLUSIONS: In contrast to health, in T2D, leucine and isoleucine, administered intragastrically in a dose of 10 g, do not lower the glycaemic response to a mixed-nutrient drink. This finding argues against a role for 'preloads' of either leucine or isoleucine in the management of T2D. | - |
dc.description.statementofresponsibility | Rachel A. Elovaris, Maryam Hajishafiee, Sina S. Ullrich, Penelope C.E. Fitzgerald,Kylie Lange, Michael Horowitz, Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2020 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.diabres.2020.108618 | - |
dc.subject | Branched-chain amino acids | - |
dc.subject | blood glucose | - |
dc.subject | glucagon | - |
dc.subject | glucoregulatory hormones | - |
dc.subject | human | - |
dc.subject | insulin | - |
dc.title | Intragastric administration of leucine and isoleucine does not reduce the glycaemic response to, or slow gastric emptying of, a carbohydrate-containing drink in type 2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.diabres.2020.108618 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1103020 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1158296 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lange, K. [0000-0003-3814-8513] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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