Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132230
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Type: | Journal article |
Title: | Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla |
Author: | Lumb, R. Tata, M. Xu, X. Joyce, A. Marchant, C. Harvey, N. Ruhrberg, C. Schwarz, Q. |
Citation: | Development (Cambridge), 2018; 145(21):62552-1-162552-8 |
Publisher: | Company of Biologists |
Issue Date: | 2018 |
ISSN: | 0950-1991 1477-9129 |
Statement of Responsibility: | Rachael Lumb, Mathew Tata, Xiangjun Xu, Andrew Joyce, Ceilidh Marchant, Natasha Harvey, Christiana Ruhrberg and Quenten Schwarz |
Abstract: | The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla and how they become connected to central nervous system-derived preganglionic sympathetic neurons remain largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3 proteins serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response. |
Keywords: | Adrenal gland; autonomic nervous system; axon guidance; chromaffin cell; neural crest cell; neuropilin |
Rights: | © 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
DOI: | 10.1242/dev.162552 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/106958 |
Published version: | http://dx.doi.org/10.1242/dev.162552 |
Appears in Collections: | Medicine publications |
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hdl_132230.pdf | Published Version | 12.37 MB | Adobe PDF | View/Open |
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