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https://hdl.handle.net/2440/132311
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Type: | Journal article |
Title: | The effects of aerobic exercise on depression-like, anxiety-like, and cognition-like behaviours over the healthy adult lifespan of C57BL/6 mice |
Author: | Morgan, J. Singhal, G. Corrigan, F. Jaehne, E. Jawahar, M. Baune, B. |
Citation: | Behavioural Brain Research, 2018; 337:193-203 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 0166-4328 1872-7549 |
Statement of Responsibility: | Julie A. Morgan, Gaurav Singhal, Frances Corrigan, Emily J. Jaehne, Magdalene C. Jawahar, Bernhard T. Baune |
Abstract: | Preclinical studies have demonstrated exercise improves various types of behaviours such as anxiety-like, depression-like, and cognition-like behaviours. However, these findings were largely conducted in studies utilising short-term exercise protocols, and the effects of lifetime exercise on these behaviours remain unknown. This study investigates the behavioural effects of lifetime exercise in normal healthy ageing C57BL/6 mice over the adult lifespan. 12 week-old C57BL/6 mice were randomly assigned to voluntary wheel running or non-exercise (control) groups. Exercise commenced at aged 3 months and behaviours were assessed in young adult (Y), early middle age (M), and old (O) mice (n=11-17/group). The open field and elevated zero maze examined anxiety-like behaviours, depression-like behaviours were quantified with the forced swim test, and the Y maze and Barnes maze investigated cognition-like behaviours. The effects of lifetime exercise were not simply an extension of the effects of chronic exercise on anxiety-like, depression-like, and cognition-like behaviours. Exercise tended to reduce overt anxiety-like behaviours with ageing, and improved recognition memory and spatial learning in M mice as was expected. However, exercise also increased anxiety behaviours including greater freezing behaviour that extended spatial learning latencies in Y female mice in particular, while reduced distances travelled contributed to longer spatial memory and cognitive flexibility latencies in Y and O mice. Lifetime exercise may increase neurogenesis-associated anxiety. This could be an evolutionary conserved adaptation that nevertheless has adverse impacts on cognition-like function, with particularly pronounced effects in Y female mice with intact sex hormones. These issues require careful investigation in future rodent studies. |
Keywords: | Aging; anxiety; cognition; depression; exercise |
Rights: | © 2017 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.bbr.2017.09.022 |
Published version: | http://dx.doi.org/10.1016/j.bbr.2017.09.022 |
Appears in Collections: | Psychiatry publications |
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