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Type: Journal article
Title: Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions
Author: Zou, D.
Wu, Z.
Yi, X.
Hui, Y.
Yang, G.
Liu, Y.
Wang, H.
Brooks, A.
Wang, H.
Liu, X.
Xu, Z.P.
Roberts, M.S.
Gao, H.
Zhao, C.-X.
Citation: Proceedings of the National Academy of Sciences of USA, 2023; 120(1):e2214757120-e2214757120
Publisher: Proceedings of the National Academy of Sciences
Issue Date: 2023
ISSN: 0027-8424
Statement of
Da Zou, Zeming Wu, Xin Yi, Yue Hui, Guangze Yang, Yun Liu, Tengjisi, Haofei Wang, Anastasia Brooks, Haolu Wang, Xin Liu, Zhi Ping Xu, Michael S. Roberts, Huajian Gao, and Chun-Xia Zhao
Abstract: Cell membrane-coated nanoparticles are emerging as a new type of promising nanomaterials for immune evasion and targeted delivery. An underlying premise is that the unique biological functions of natural cell membranes can be conferred on the inherent physiochemical properties of nanoparticles by coating them with a cell membrane. However, the extent to which the membrane protein properties are preserved on these nanoparticles and the consequent bio-nano interactions are largely unexplored. Here, we synthesized two mesenchymal stem cell (MSC) membrane-coated silica nanoparticles (MCSNs), which have similar sizes but distinctly different stiffness values (MPa and GPa). Unexpectedly, a much lower macrophage uptake, but much higher cancer cell uptake, was found with the soft MCSNs compared with the stiff MCSNs. Intriguingly, we discovered that the soft MCSNs enabled the forming of a more protein-rich membrane coating and that coating had a high content of the MSC chemokine CXCR4 and MSC surface marker CD90. This led to the soft MCSNs enhancing cancer cell uptake mediated by the CD90/integrin receptor-mediated pathway and CXCR4/SDF-1 pathways. These findings provide a major step forward in our fundamental understanding of how the combination of nanoparticle elasticity and membrane coating may be used to facilitate bio-nano interactions and pave the way forward in the development of more effective cancer nanomedicines.
Keywords: nanoparticles
cell membrane coating
Rights: © 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
DOI: 10.1073/pnas.2214757120
Grant ID:
Appears in Collections:Chemical Engineering publications

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