Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138870
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Type: | Journal article |
Title: | A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study |
Author: | Saul, A.M. Taylor, B.V. Blizzard, L. Simpson-Yap, S. Oddy, W.H. Shivappa, N. Hébert, J.R. Black, L.J. Ponsonby, A.L. Broadley, S.A. Lechner-Scott, J. van der Mei, I. Lucas, R.M. Dear, K. Dwyer, T. Broadley, S. Kilpatrick, T. Williams, D. Shaw, C. Chapman, C. et al. |
Citation: | Multiple Sclerosis Journal, 2023; 29(8):1012-1023 |
Publisher: | SAGE Publications |
Issue Date: | 2023 |
ISSN: | 1352-4585 1477-0970 |
Statement of Responsibility: | Alice M Saul, Bruce V Taylor, Leigh Blizzard, Steve Simpson-Yap, Wendy H Oddy, Nittin Shivappa, James R Hébert, Lucinda J Black, Anne-Louise Ponsonby, Simon A Broadley, Jeanette Lechner-Scott and Ingrid van der Mei, Ausimmune, AusLong Investigators Group |
Abstract: | Background: A pro-inflammatory diet has been posited to induce chronic inflammation within the central nervous system (CNS), and multiple sclerosis (MS) is an inflammatory disease of the CNS. Objective: We examined whether Dietary Inflammatory Index (DII®)) scores are associated with measures of MS progression and inflammatory activity. Methods: A cohort with a first clinical diagnosis of CNS demyelination was followed annually (10 years, n=223). At baseline, 5- and 10-year reviews, DII and energy-adjusted DII (E-DIITM) scores were calculated (food frequency questionnaire) and assessed as predictors of relapses, annualised change in disability (Expanded Disability Status Scale) and two magnetic resonance imaging measures; fluid-attenuated inversion recovery (FLAIR) lesion volume and black hole lesion volume. Results: A more pro-inflammatory diet was associated with a higher relapse risk (highest vs. lowest E-DII quartile: hazard ratio=2.24, 95% confidence interval (CI)= −1.16, 4.33, p=0.02). When we limited analyses to those assessed on the same manufacturer of scanner and those with a first demyelinating event at study entry (to reduce error and disease heterogeneity), an association between E-DII score and FLAIR lesion volume was evident (β=0.38, 95% CI=0.04, 0.72, p=0.03). Conclusion: There is a longitudinal association between a higher DII and a worsening in relapse rate and periventricular FLAIR lesion volume in people with MS. |
Keywords: | Diet; inflammation; dietary inflammatory index; multiple sclerosis; MRI; EDSS; time to relapse and conversion to MS |
Description: | First published online May 6, 2023 |
Rights: | © The Author(s), 2023. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Article reuse guidelines: https://au.sagepub.com/en-gb/oce/journals-permissions |
DOI: | 10.1177/13524585231167739 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/316901 http://purl.org/au-research/grants/nhmrc/224215 |
Published version: | http://dx.doi.org/10.1177/13524585231167739 |
Appears in Collections: | Public Health publications |
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hdl_138870.pdf | Published version | 207.24 kB | Adobe PDF | View/Open |
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