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|Title:||Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men|
|Citation:||Peptides, 2006; 27(7):1638-1643|
|Publisher:||Elsevier Science Inc|
|Kate L. Feltrin, Michael Patterson, Mohammad A. Ghatei, Stephen R. Bloom, James H. Meyer, Michael Horowitz, Christine Feinle-Bisset|
|Abstract:||We have evaluated the effects of fatty acid chain length on ghrelin, peptide YY (PYY), glucagon-like peptide-2 (GLP-2) and pancreatic polypeptide (PP) secretion and hypothesized that intraduodenal administration of dodecanoic ("C12"), but not decanoic ("C10"), acid would decrease plasma ghrelin and increase PYY, GLP-2 and PP concentrations. Plasma hormone concentrations were measured in seven healthy men during 90-min intraduodenal infusions of: (i) C12, (ii) C10 or (iii) control (rate: 2 ml/min, 0.375 kcal/min for C12/C10) and after a buffet-meal consumed following the infusion. C12 markedly suppressed plasma ghrelin and increased both PYY and GLP-2 (all P < 0.05) compared with control and C10, while C10 had no effect. Both C10 and C12 increased PP concentrations slightly (P < 0.05). We conclude that the effects of intraduodenal fatty acids on ghrelin, PYY and GLP-2 secretion are dependent on their chain length.|
|Keywords:||Duodenum; Animals; Humans; Rats; Peptide YY; Pancreatic Polypeptide; Peptide Hormones; Fatty Acids; Feeding Behavior; Time Factors; Adult; Middle Aged; Male; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Ghrelin|
|Rights:||© 2006 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Medicine publications|
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