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https://hdl.handle.net/2440/28174
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Type: | Journal article |
Title: | Pathogen occurrence and antimicrobial resistance trends among urinary tract infection isolates in the Asia-Western Pacific Region: report from the SENTRY Antimicrobial Surveillance Program, 1998-1999 |
Author: | Turnidge, J. Bell, J. Biedenbach, D. Jones, R. |
Citation: | International Journal of Antimicrobial Agents, 2002; 20(1):10-17 |
Publisher: | Elsevier Science BV |
Issue Date: | 2002 |
ISSN: | 0924-8579 1872-7913 |
Statement of Responsibility: | John Turnidge, Jan Bell, Douglas J. Biedenbach and Ronald N. Jones |
Abstract: | Worldwide surveillance of antimicrobial resistance among urinary tract pathogens is useful to determine important trends and geographical variation for common Gram-positive and -negative species. The most common causative uropathogens often have intrinsic or acquired resistance mechanisms which include ESBL production among enteric bacilli, multi-drug resistant staphylococci and non-fermentative Gram-negative bacilli such as Pseudomonas aeruginosa and Acinetobacter spp. and vancomycin-resistant Enterococcus spp. This study evaluates pathogen frequency and the resistance rates among urinary tract infection (UTI) pathogens in 14 medical centres in the Asia-Pacific region between 1998 and 1999. The isolates were referred to a central monitor for reference NCCLS broth microdilution testing, identification confirmation and patient demographic analysis. Over 50% of the 958 pathogens were Escherichia coli and Klebsiella spp. followed by P. aeruginosa, Enterococcus spp. and Enterobacter spp. Susceptibility for the three enteric bacilli was high for carbapenems (100%), 'fourth-generation' cephalosporins (cefepime 94.9-98.6%) and amikacin (> or = 93.0%). Beta-lactamase inhibitor compounds were more active against E. coli (piperacillin/tazobactam; > 90% susceptible) than the other two enteric species and all other tested agents had a narrower spectra of activity. The rank order of anti-pseudomonal agents was amikacin (91.5% susceptible)> imipenem > piperacillin/tazobactam > tobramycin > ceftazidime and cefepime (77.4 and 76.4% susceptible, respectively). Susceptibility to quinolones for the P. aeruginosa isolates was only 63.2-67.0%. Only one vancomycin-intermediate Enterococcus spp. (van C phenotype) was detected among the 103 strains tested. Newer fluoroquinolones (gatifloxacin; MIC(50), mg/l) were more potent against enterococci than ciprofloxacin (MIC(50), 2 mg/l) and high-level resistance to aminoglycosides was common (41.7%). The data presented are compared to studies of similar design from other areas which are part of the SENTRY surveillance network. |
Keywords: | Humans Gram-Negative Bacteria Gram-Positive Bacteria Urinary Tract Infections Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Microbial North America Asia Female Global Health |
Description: | Copyright © 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved. |
DOI: | 10.1016/S0924-8579(02)00050-X |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/505521/description#description |
Published version: | http://dx.doi.org/10.1016/s0924-8579(02)00050-x |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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