Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/35777
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Type: Journal article
Title: Integrative assessment of brain function in PTSD: brain stability and working memory
Author: Veltmeyer, M.
McFarlane, A.
Bryant, R.
Mayo, T.
Gordon, E.
Clark, C.
Citation: Journal of Integrative Neuroscience, 2006; 5(1):123-138
Publisher: Inperial College Press
Issue Date: 2006
ISSN: 0219-6352
1757-448X
Statement of
Responsibility: 
Melinda D. Veltmeyer; Alexander C. McFarlane; Richard A. Bryant; Therese Mayo; Evian Gordon; C. Richard Clark
Abstract: Posttraumatic Stress Disorder (PTSD) is characterized by symptoms of hyperarousal, avoidance and intrusive trauma-related memories and deficits in everyday memory and attention. Separate studies in PTSD have found abnormalities in electroencephalogram EEG, in event-related potential (ERP) and behavioral measures of working memory and attention. The present study seeks to determine whether these abnormalities are related and the extent to which they share this relationship with clinical symptoms. EEG data were collected during an eyes-open paradigm and a one-back working memory task. Behavioral and clinical data (CAPS) were also collected. The PTSD group showed signs of altered cortical arousal as indexed by reduced alpha power and an increased theta/alpha ratio, and clinical and physiological measures of arousal were found to be related. The normal relationship between theta power and ERP indices of working memory was not affected in PTSD, with both sets of measures reduced in the disordered group. Medication appeared to underpin a number of abnormal parameters, including P3 amplitude to targets and the accuracy, though not speed, of target detection. The present study helps to overcome a limitation of earlier studies that assess such parameters independently in different groups of patients that vary in factors such as comorbidity, medication status, gender and symptom profile. The present study begins to shed light on the relationship between these measures and suggests that abnormalities in brain working memory may be linked to underlying abnormalities in brain stability.
Keywords: Brain; Humans; Electroencephalography; Brain Mapping; Analysis of Variance; Case-Control Studies; Memory, Short-Term; Attention; Reaction Time; Stress Disorders, Post-Traumatic; Evoked Potentials, Auditory; Adult; Middle Aged; Female; Male
Description: Copyright © 2006 Imperial College Press
RMID: 0020062112
DOI: 10.1142/S0219635206001057
Appears in Collections:Psychiatry publications

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