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https://hdl.handle.net/2440/37056
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Type: | Journal article |
Title: | Androgen metabolic genes in prostate cancer predisposition and progression |
Author: | Makridakis, N. Buchanan, G. Tilley, W. Reichardt, J. |
Citation: | Frontiers in Bioscience, 2005; 10(SUPPL. 3):2892-2903 |
Publisher: | Frontiers in Bioscience Inc |
Issue Date: | 2005 |
ISSN: | 1093-9946 2768-6698 |
Statement of Responsibility: | Nick M. Makridakis, Grant Buchanan, Wayne Tilley and Juergen K. V. Reichardt |
Abstract: | Significant evidence implicates androgens in prostate cancer etiology. We review recent data with regard to the association between several allelic variants of specific androgen-metabolic genes and the predisposition to prostate cancer. We also review the emerging evidence regarding the role of genetic variants of these genes as well as the androgen receptor in prostate cancer progression. Based on the prostate cancer paradigm, we propose that a multidisciplinary attack on the problem--involving biochemistry, genetics, pharmacogenetics, endocrinology and molecular epidemiology--may be important for the understanding and successful treatment of complex (in terms of etiology) human diseases. |
Keywords: | Humans Prostatic Neoplasms Disease Progression Genetic Predisposition to Disease Steroid 17-alpha-Hydroxylase Hydroxysteroid Dehydrogenases Mixed Function Oxygenases Receptors, Androgen Androgens Male |
Description: | © 2005 Frontiers in Bioscience |
DOI: | 10.2741/1745 |
Description (link): | http://www.bioscience.org/2005/v10/af/1745/list.htm |
Published version: | http://dx.doi.org/10.2741/1745 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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