Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/39010
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Type: Journal article
Title: Fibrillating areas isolated within the left atrium after radiofrequency linear catheter ablation
Author: Rostock, T.
Rotter, M.
Sanders, P.
Jais, P.
Hocini, M.
Takahashi, Y.
Sacher, F.
Jonsson, A.
O'Neill, M.
Hsu, L.
Clementy, J.
Haissaguerre, M.
Citation: Journal of Cardiovascular Electrophysiology, 2006; 17(8):807-812
Publisher: Futura Publ Co
Issue Date: 2006
ISSN: 1045-3873
1540-8167
Statement of
Responsibility: 
Thomas Rostock, Martin Rotter, Prashanthan Sanders, Pierre Jaïs, Mélèze Hocini, Yoshihide Takahashi, Fréderic Sacher, Anders Jönsson, Mark D. O’Neill, Li-Fern Hsu, Jacques Clémenty, and Michel Haîssaguerre
Abstract: INTRODUCTION: Nonpulmonary vein sources have been implicated as potential drivers of atrial fibrillation (AF). This observational study describes regions of fibrillating atrial tissue isolated inadvertently from the left atrium (LA) following linear catheter ablation for AF. METHODS AND RESULTS: We report four patients with persistent/permanent AF who underwent pulmonary vein isolation with additional linear lesions and who presented with recurrent AF (mean AF cycle length [AFCL] 175-270 ms). Further catheter ablation resulted in the inadvertent electrical isolation of significant areas of the LA in which AF persisted at the same AFCL as was measured prior to disconnection, despite the restoration of sinus rhythm (SR) in all other left and right atrial areas, strongly suggesting that these islands were driving the remaining atria into fibrillation. The disconnected areas were located in the lateral LA, including the left atrial appendage (LAA) in three patients (limited to the LAA in one) and in the posterior LA in one patient. These isolated fibrillating regions represented 15-24% of the global LA surface, as estimated by electroanatomic mapping. CONCLUSION: Fibrillation can be maintained within electrically isolated regions of the LA following catheter ablation of AF, demonstrating the importance of atrial drivers in the maintenance of AF. Further mapping of these drivers is needed to characterize their mechanism and thereby allow for a more specific ablation strategy.
Keywords: atrial fibrillation; catheter ablation; dissimilar rhythms; mapping; linear ablation; mechanisms
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020071809
DOI: 10.1111/j.1540-8167.2006.00505.x
Published version: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1540-8167.2006.00505.x
Appears in Collections:Medicine publications

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