Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/39212
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Type: Journal article
Title: Biventricular pacing and left ventricular pacing in heart failure: similar hemodynamic improvement despite marked electromechanical differences
Author: Bordachar, P.
Lafitte, S.
Reuter, S.
Garrigue, S.
Sanders, P.
Roudaut, R.
Jais, P.
Haissaguerre, M.
Clementy, J.
Citation: Journal of Cardiovascular Electrophysiology, 2004; 15(12):1342-1347
Publisher: Futura Publ Co
Issue Date: 2004
ISSN: 1045-3873
1540-8167
Statement of
Responsibility: 
Pierre Bordachar, Stephane Lafitte, Sylvain Reuter, Stephane Garrigue, Prashanthan Sanders, Raymond Roudaut, Pierre Jaïs, Michel Haïssaguerre, Jacques Clementy
Abstract: Introduction: We conducted an acute echocardiographic study comparing hemodynamic and ventricular dyssynchrony parameters during left ventricular pacing (LVP) and biventricular pacing (BVP). We sought to clarify the mechanisms responsible for similar hemodynamic improvement despite differences in electrical activation. Methods and Results: Thirty-three patients underwent echocardiography prior to implantation with a multisite pacing device (spontaneous rhythm [SR]) and 2 days after implantation (BVP and LVP). Interventricular dyssynchrony (pulsed-wave Doppler), extent of myocardium displaying delayed longitudinal contraction (%DLC; tissue tracking), and index of LV dyssynchrony (pulsed-wave tissue Doppler imaging) were assessed. Compared to SR, BVP and LVP caused similar significant improvement of cardiac output (LVP: 3.2 ± 0.5, BVP: 3.1 ± 0.7, SR: 2.3 ± 0.6 L/min; P < 0.01) and mitral regurgitation (LVP: 25.1 ± 10, BVP: 24.7 ± 11, baseline: 37.9 ± 14% jet area/left atria area; P < 0.01). LVP resulted in a smaller index of LV dyssynchrony than BVP (29 ± 10 vs 34 ± 14; P < 0.05). However, LVP exhibited a longer aortic preejection delay (220 ± 34 vs 186 ± 28 msec; P < 0.01), longer LV electromechanical delays (244.5 ± 39 vs 209.5 ± 47 msec; P < 0.05), greater interventricular dyssynchrony (56.6 ± 18 vs 31.4 ± 18; P < 0.01), and higher%DLC (40.1 ± 08 vs 30.3 ± 09; P < 0.05), leading to shorter LV filling time (387 ± 54 vs 348 ± 44 msec; P < 0.05) compared to BVP. Conclusion: Although LVP and BVP provide similar hemodynamic improvement, LVP results in more homogeneous but substantially delayed LV contraction, leading to shortened filling time and less reduction in postsystolic contraction. These data may influence the choice of individual optimal pacing configuration.
Keywords: Humans; Cardiac Output, Low; Ventricular Dysfunction, Left; Echocardiography, Doppler; Cardiac Pacing, Artificial; Analysis of Variance; Aged; Female; Male; Heart Failure; Hemodynamics
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020071852
DOI: 10.1046/j.1540-8167.2004.04318.x
Published version: http://www.blackwell-synergy.com/doi/abs/10.1046/j.1540-8167.2004.04318.x
Appears in Collections:Medicine publications

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