Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/50773
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Takano, S. | - |
dc.contributor.author | Ando, T. | - |
dc.contributor.author | Hiramatsu, N. | - |
dc.contributor.author | Kanayama, A. | - |
dc.contributor.author | Maekawa, S. | - |
dc.contributor.author | Ohnuma, Y. | - |
dc.contributor.author | Enomoto, N. | - |
dc.contributor.author | Ogawa, H. | - |
dc.contributor.author | Paton, A. | - |
dc.contributor.author | Paton, J. | - |
dc.contributor.author | Kitamura, M. | - |
dc.contributor.author | Nakao, A. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2008; 371(4):762-766 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50773 | - |
dc.description | Copyright © 2008 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V. | - |
dc.description.abstract | The 78-kDa glucose-regulated protein (GRP78) is an important molecular chaperone in the endoplasmic reticulum (ER) induced by various stresses. This study showed that stimulation with anti-CD3 mAb, PMA plus ionomycin, or an antigen increased the levels of GRP78 mRNA in primary T cells, which was inhibited by Ca2+ chelators EGTA and BAPTA-AM and by an inhibitor of calcineurin FK506. In addition, the specific knockdown of GRP78 protein expression induced apoptosis in mouse EL-4 T cell line associated with CHOP induction and caspase-3 activation. Furthermore, overexpression of GRP78 inhibited PMA/ionomycin-induced cell death in EL-4 cells. Collectively, GRP78 expression is induced by TCR activation via a Ca2+-dependent pathway and may play a critical role in maintaining T cell viability in the steady and TCR-activated states. These results suggest a novel regulatory mechanism and an essential function of GRP78 in T cells. | - |
dc.description.statementofresponsibility | Shinichi Takano, Takashi Ando, Nobuhiko Hiramatsu, Asuka Kanayama, Shinya Maekawa, Yuko Ohnuma, Nobuyuki Enomoto, Hideoki Ogawa, Adrienne W. Paton, James C. Paton, Masanori Kitamura and Atsuhito Nakao | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bbrc.2008.04.132 | - |
dc.subject | GRP78/BiP | - |
dc.subject | T cells | - |
dc.subject | T cell receptor | - |
dc.subject | Apoptosis | - |
dc.title | T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.04.132 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Paton, J. [0000-0001-9807-5278] | - |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.