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https://hdl.handle.net/2440/50945
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DC Field | Value | Language |
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dc.contributor.author | Vitry, A. | - |
dc.contributor.author | Wong, S. | - |
dc.contributor.author | Roughead, E. | - |
dc.contributor.author | Ramsay, E. | - |
dc.contributor.author | Barratt, J. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Australian and New Zealand Journal of Public Health, 2009; 33(2):126-130 | - |
dc.identifier.issn | 1326-0200 | - |
dc.identifier.issn | 1753-6405 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50945 | - |
dc.description | © 2009 The Authors. Journal Compilation © 2009 Public Health Association of Australia | - |
dc.description.abstract | <h4>Objectives</h4>To determine the validity of two medication-based co-morbidity indices, the Medicines Disease Burden Index (MDBI) and Rx-Risk-V in the Australian elderly population.<h4>Methods</h4>In Phase I, the sensitivity and specificity of both indices were determined in 767 respondents from wave 6 of the Australian Longitudinal Study of Ageing (ALSA). Medication-defined index disease categories were compared to self-reported medical conditions. Correlation with self-rated health was examined and Cox proportional hazards models were used to assess the predictive validity for mortality. Phase II verified the predictive ability of Rx-Risk-V in a sample of 213,191 veterans from Australian Department of Veterans' Affairs (DVA) database.<h4>Results</h4>MDBI and Rx-Risk-V scores could be calculated for 28% and 73% of the ALSA sample respectively. Both indices had high specificities and low to moderate sensitivities compared to self-reported medical conditions. Total weighted scores were significantly related to self-rated health (p<0.001). Both indices were predictive of mortality (Hazard Ratio (HR) =3.690 (95% CI 2.264-6.015) for MDBI and HR 1.079 (95% CI 1.045-1.114) for Rx-Risk-V. The predictive validity for mortality of Rx-Risk-V was confirmed using DVA data (HR= 1.090, 95% CI 1.088-1.092).<h4>Conclusions</h4>Medication-based co-morbidity indices Rx-Risk-V and MDBI are valid measures of co-morbidity. However, Rx-Risk-V detects more comorbidity in the Australian elderly population and is likely to be a more suitable index to use in administrative datasets, particularly where studies include large numbers of outpatients. | - |
dc.description.statementofresponsibility | Agnes Vitry, Soo Ann Wong, Elizabeth E. Roughead, Emmae Ramsay, John Barratt | - |
dc.language.iso | en | - |
dc.publisher | Public Health Assoc Australia Inc | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1753-6405.2009.00357.x | - |
dc.subject | co-morbidity | - |
dc.subject | chronic disease/drug therapy | - |
dc.subject | drug prescriptions | - |
dc.subject | risk adjustment/methods | - |
dc.title | Validity of medication-based co-morbidity indices in the Australian elderly population | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1753-6405.2009.00357.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Public Health publications |
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