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https://hdl.handle.net/2440/54740
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Type: | Journal article |
Title: | Activities of Dalbavancin against a Worldwide Collection of 81,673 Gram-Positive Bacterial Isolates |
Author: | Biedenbach, D. Bell, J. Sader, H. Turnidge, J. Jones, R. |
Citation: | Antimicrobial Agents and Chemotherapy, 2009; 53(3):1260-1263 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2009 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Douglas J. Biedenbach, Jan M. Bell, Helio S. Sader, John D. Turnidge and Ronald N. Jones |
Abstract: | Dalbavancin, a long-acting lipoglycopeptide, was evaluated against 81,673 isolates of staphylococci, enterococci, and streptococci collected from 33 countries during worldwide resistance surveillance (2002 to 2007). Regardless of susceptibility to oxacillin, comparable potencies for dalbavancin against Staphylococcus aureus and coagulase-negative staphylococci from all countries were noted (MIC(90), 0.06 to 0.12 microg/ml). Vancomycin-susceptible Enterococcus spp. had dalbavancin MIC(90)s comparable to those for staphylococci, whereas vancomycin-resistant strains were more resistant (MIC(50), >4 microg/ml). beta-Hemolytic and viridians group streptococci were very susceptible to dalbavancin (MIC(90), <or=0.03 microg/ml). Overall, dalbavancin was >or=16-fold more active than vancomycin against the monitored gram-positive species. |
Keywords: | Humans Gram-Positive Bacteria Teicoplanin Vancomycin Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Bacterial Quality Control Latin America North America Asia Europe Pacific Ocean |
Description: | Copyright © 2009, American Society for Microbiology. |
DOI: | 10.1128/AAC.01453-08 |
Published version: | http://dx.doi.org/10.1128/aac.01453-08 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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