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Type: Journal article
Title: Esterase D is essential for protection of Neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells
Author: Potter, Adam Joseph
Kidd, Stephen Peter
Edwards, Jennifer L.
Falsetta, Megan L.
Apicella, Michael A.
Jennings, Michael Paul
McEwan, Alastair G.
Citation: Journal of Infectious Diseases, 2009; 200(2):273-278
Publisher: University of Chicago Press
Issue Date: 2009
ISSN: 0022-1899
School/Discipline: School of Molecular and Biomedical Science
Statement of
Adam J. Potter, Stephen P. Kidd, Jennifer L. Edwards, Megan L. Falsetta, Michael A. Apicella, Michael P. Jennings and Alastair G. McEwan
Abstract: estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S‚Äźnitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.
RMID: 0020093251
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Appears in Collections:Molecular and Biomedical Science publications

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