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https://hdl.handle.net/2440/57069
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Type: | Journal article |
Title: | Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections |
Author: | Florido, M. McColl, S. Appelberg, R. |
Citation: | Immunobiology, 2009; 214(8):643-652 |
Publisher: | Urban & Fischer Verlag |
Issue Date: | 2009 |
ISSN: | 0171-2985 1878-3279 |
Statement of Responsibility: | Manuela Flórido, Shaun R. McColl and Rui Appelberg |
Abstract: | CD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD153 interactions are involved in lung immune-mediated inflammation. |
Keywords: | Mycobacteria T cells Cell-mediated immunity Lung |
Description: | Copyright © 2009 Elsevier GmbH All rights reserved. |
DOI: | 10.1016/j.imbio.2008.12.002 |
Published version: | http://dx.doi.org/10.1016/j.imbio.2008.12.002 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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